C-Reactive Protein antibody

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Sheep anti Human C-Reactive Protein

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG

Product Code	Applications	Datasheet	MSDS	Pack Size	List Price	Quantity
1707-0306G	C E			1 ml

Sheep anti Human C-Reactive Protein antibody detects human C-reactive protein (CRP), a calcium-binding plasma protein which is significantly up-regulated during the acute phase response. CRP has been shown to bind phosphocholine residues, apoptotic cells and constituents of micro-organisms, and can lead to activation of leukocytes and the complement system, and the clearance of apoptotic cells.

CRP is produced in the liver in response to interleukin-1 (IL-1) and IL-6 secretion, and has a monomer molar mass of 25 kDa, and native cyclic pentamer mass of 125 kDa.

Product Details

Target Species: Human
Product Form: Purified IgG - liquid
Antiserum Preparation: Antisera to human CRP were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein G.
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
Immunogen: Native, from serum
Approx. Protein Concentrations: IgG concentration 5.0mg/ml

Storage Information

Storage: Store at +4^oC or at -20^oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

More Information

UniProt: P02741 Related reagents
Entrez Gene: CRP Related reagents
GO Terms: GO:0005515 protein binding; GO:0006953 acute-phase response; GO:0046872 metal ion binding; GO:0008228 opsonization; GO:0010745 negative regulation of macrophage derived foam cell differentiation; GO:0010888 negative regulation of lipid storage; GO:0030169 low-density lipoprotein particle binding; GO:0033265 choline binding; GO:0051637 Gram-positive bacterial cell surface binding
Regulatory: For research purposes only

Applications of C-Reactive Protein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA
Immunohistology - Frozen

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Secondary Antibodies Available

Description	Product Code	Pack Size	Applications
Rabbit anti Sheep IgG (H/L):Biotin	5184-2304	1.5 ml	C E F WB
Donkey anti Sheep/Goat IgG:DyLight®488	STAR88D488GA	0.1 mg	F IF
Donkey anti Sheep/Goat IgG:DyLight®549	STAR88D549GA	0.1 mg	F IF
Donkey anti Sheep/Goat IgG:DyLight®649	STAR88D649GA	0.1 mg	F IF
Donkey anti Sheep/Goat IgG:FITC	STAR88F	1 mg	C
Donkey anti Sheep/Goat IgG:HRP	STAR88P	1 ml	C E P WB

Useful Reagents Available

Description	Product Code	Pack Size	Applications
Histar Detection System	STAR3000A	50 Tests	C P
Histar Detection System	STAR3000B	150 Tests	C P
Histar Detection System	STAR3000C	500 Tests	C P