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C-Reactive Protein antibody

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Native Human C-Reactive Protein detected with Sheep anti Human C-Reactive Protein (1707-0306G).

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Sheep anti Human C-Reactive Protein

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
C-Reactive Protein

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Product Code Applications Pack Size List Price Your Price Qty
1707-0306G
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E 1 ml
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Sheep anti Human C-Reactive Protein antibody detects human C-reactive protein (CRP), a calcium-binding plasma protein which is significantly up-regulated during the acute phase response. CRP has been shown to bind phosphocholine residues, apoptotic cells and constituents of micro-organisms, and can lead to activation of leukocytes and the complement system, and the clearance of apoptotic cells.

CRP is produced in the liver in response to interleukin-1 (IL-1) and IL-6 secretion, and has a monomer molar mass of 25 kDa, and native cyclic pentamer mass of 125 kDa.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human CRP were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on Protein G.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Native c-reactive protein, from serum
Approx. Protein Concentrations
IgG concentration 5.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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Further Reading

  1. DeFerranti, S.D. & Rifai, N. (2007) C-reactive protein: a nontraditional serum marker of cardiovascular risk.
    Cardiovasc Pathol. 16 (1): 14-21.
  2. Yeh, E.T. (2004) CRP as a mediator of disease.
    Circulation. 109 (21 Suppl 1): II11-4.

Synonyms
CRP
RRID
AB_1510170
UniProt
P02741
Entrez Gene
CRP
GO Terms
GO:0005515 protein binding
GO:0006953 acute-phase response
GO:0046872 metal ion binding
GO:0008228 opsonization
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030169 low-density lipoprotein particle binding
GO:0033265 choline binding
GO:0051637 Gram-positive bacterial cell surface binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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