Beta Amyloid antibody

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Rabbit anti Human Beta Amyloid (aa1-42)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP677 C E P* WB 0.1 ml
Rabbit anti Human beta amyloid antibody recognizes the beta amyloid (1-42) peptide, the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease (Benveniste et al. 2015). Beta amyloid also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy (Kirshner et al. 2015).

Rabbit anti Human beta amyloid antibody (AHP677) may be used in immunohistochemical staining of Alzheimer's disease plaques.

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to Beta amyloid (1-42) were raised by repeated immunisations of rabbits with highly purified antigen.
Preservative Stabilisers
0.02%Sodium Azide

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P05067 Related reagents
Entrez Gene
APP Related reagents
Regulatory
For research purposes only

Applications of Beta Amyloid antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Frozen
Immunohistology - Paraffin 1
Western Blotting 1/500 1/1000
  1. 1This product requires formic acid pre-treatment of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Alzheimer's disease brain

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
TidyBlot Western Blot Detection Reagent:HRP STAR209P 0.5 ml WB*

Application Based External Images

Immunohistology - Frozen

Product Specific References

References for Beta Amyloid antibody

  1. Bertrand, E. et al (2008) Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study.
    Folia Neuropathologica. 46: 255-269.
  2. Carty, N.C. et al. (2006) Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice.
    J Neuroinflammation. 3: 11.
  3. Jeffrey, M. et al. (2015) Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer's precursor protein (APP).
    Neuropathol Appl Neurobiol. 41 (4): 458-70.
  4. Jeffrey M et al. (2015) A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK.
    PLoS One. 10 (6): e0129499.