Rabbit anti Human beta amyloid antibody
recognizes the beta amyloid (1-42) peptide, the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease (Benveniste et al. 2015). Beta amyloid also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy (Kirshner et al. 2015).
Rabbit anti Human beta amyloid antibody (AHP677) may be used in immunohistochemical staining of Alzheimer's disease plaques.
- Target Species
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to Beta amyloid (1-42) were raised by repeated immunisations of rabbits with highly purified antigen.
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Beta Amyloid antibody
|Immunohistology - Frozen
|Immunohistology - Paraffin 1
- 1This product requires formic acid pre-treatment of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Alzheimer's disease brain
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Secondary Antibodies Available
Useful Reagents Available
Application Based External Images
Immunohistology - Frozen
Product Specific References
References for Beta Amyloid antibody
Bertrand, E. et al (2008) Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study.
Folia Neuropathologica. 46: 255-269.
Carty, N.C. et al. (2006) Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice.
J Neuroinflammation. 3: 11.
Jeffrey, M. et al. (2015) Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer's precursor protein (APP).
Neuropathol Appl Neurobiol. 41 (4): 458-70.
Jeffrey M et al. (2015) A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK.
PLoS One. 10 (6): e0129499.
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