Bcl-xL antibody

Rabbit anti Human Bcl-xL

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Bcl-xL

Product Code Applications Pack Size List Price Your Price Qty
AHP1722
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SDS Safety Datasheet SDS
WB 0.1 mg loader
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Rabbit anti Human Bcl-xL antibody recognizes the long isoform of human Bcl-2-like protein 1, otherwise known as Bcl-xL, located on the mitochondrial membrane. The Bcl-xL isoform (the longer isoform) is a potent inhibitor of apoptosis. It appears to regulate cell death by binding to and blocking the voltage-dependent anion channel, thereby preventing the release of the caspase activator cytochrome c. High expression of Bcl-xL in tumours correlates to advanced disease and a poor prognosis.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to Bcl-xL was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to 14 amino acids near the carboxy terminus of human Bcl-xL precursor.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1 2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1722 detects a band of approximately 27kDa in A549 cell lysate

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Synonyms
BCL2L1
RRID
AB_2064873
UniProt
Q07817
Entrez Gene
BCL2L1
GO Terms
GO:0001836 release of cytochrome c from mitochondria
GO:0016021 integral to membrane
GO:0005741 mitochondrial outer membrane
GO:0008629 induction of apoptosis by intracellular signals
GO:0008634 negative regulation of survival gene product expression
GO:0042802 identical protein binding
GO:0031965 nuclear membrane
GO:0034097 response to cytokine stimulus
GO:0046902 regulation of mitochondrial membrane permeability
GO:0051881 regulation of mitochondrial membrane potential
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products