Alpha 2 Macroglobulin antibody

Sheep anti Human Alpha 2 Macroglobulin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Alpha 2 Macroglobulin

Product Code Applications Pack Size List Price Your Price Qty
5850-0004
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E 1 ml
List Price Your Price
Search for Batch Specific Datasheets

Sheep anti Human alpha 2 macroglobulin antibody recognizes human alpha-2-macroglobulin, a secreted protease inhibitor known to suppress the function of all four classes of proteinases. Sheep anti Human alpha 2 macroglobulin antibody exhibits minimal cross reactivity with related serum proteins.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Purified human alpha-2 macroglobulin
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Alpha 2 Macroglobulin antibody

  1. Nedić, O. et al. (2017) Analysis of Four Circulating Complexes of Insulin-Like Growth Factor Binding Proteins in Human Blood during Aging.
    Biochemistry (Mosc). 82 (10): 1200-6.
  2. Nedić, O. et al. (2022) Major trace elements and their binding proteins in the early phase of Covid-19 infection.
    J Biol Inorg Chem. Feb 12 [Epub ahead of print].

RRID
AB_620382
UniProt
P01023
Entrez Gene
A2M
GO Terms
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002576 platelet degranulation
GO:0005829 cytosol
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005615 extracellular space
GO:0007264 small GTPase mediated signal transduction
GO:0007597 blood coagulation, intrinsic pathway
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0030168 platelet activation
GO:0031093 platelet alpha granule lumen
GO:0043120 tumor necrosis factor binding
GO:0051056 regulation of small GTPase mediated signal transduction