CD90 antibody | T11D7e

Mouse anti Rat CD90

Product Type
Monoclonal Antibody
Clone
T11D7e
Isotype
IgM
Specificity
CD90

Product Code Applications Pack Size List Price Your Price Qty
MCA04G
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SDS Safety Datasheet SDS
CT F 0.25 mg loader
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loader
MCA04GT
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CT F 25 µg loader
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Mouse anti Rat CD90 antibody, clone T11D7e recognizes mouse and rat CD90 also known as Thy1.1. Thy1.1 is a monomorphic determinant in rat but polymorphic in mice. Clone T11D7e reacts with Thy1.1 mice e.g. AKR and FVB mice, but not Thy1.2 mice such as CBA and BALB/c.

Clone T11D7e is useful for removal of T lymphocytes from cell populations by complement mediated cytotoxicity (Lake et al. 1979).

Mouse anti Rat CD90 antibody, clone T11D7e is routinely tested in flow cytometry using mouse thymocytes.

Target Species
Rat
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Ig fraction - liquid
Preparation
Ig fraction prepared by ammonium sulphate precipitation from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
Immunogen
Xenogeneic rat thymocytes.
Approx. Protein Concentrations
IgM concentration 1 mg/ml
Fusion Partners
Spleen cells from immunised CBA mice were fused with cells of the mouse NS1 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC.

DO NOT FREEZE.

This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Cytotoxic Assays
Flow Cytometry 1/5
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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References for CD90 antibody

  1. Lake, P. et al. (1979) Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets.
    Eur J Immunol. 9 (11): 875-86.
  2. Mahanthappa, N.K. et al. (1996) Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth.
    J Neurosci. 16: 4673-83.
  3. Yasumizu, R. et al. (1988) Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice.
    J Immunol. 141 (6): 2181-6.
  4. Fabian, R.H. (1990) Uptake of antineuronal IgM by CNS neurons: comparison with antineuronal IgG.
    Neurology. 40 (3 Pt 1): 419-22.
  5. Ogasawara, K. et al. (1990) Ia restriction specificity of KLH-specific T cells from allogeneic bone marrow chimeras is influenced by histocompatibility at the H-2 and minor histocompatibility loci.
    Microbiol Immunol. 34 (12): 1025-39.
  6. Heinen, A. et al. (2015) Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype.
    Exp Neurol. 271: 25-35.
  7. Dietrich, N. et al. (2016) The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy.
    PLoS One. 11 (12): e0167853.
  8. Pasten, C. et al. (2015) ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1.
    Mol Cell Neurosci. 69: 1-11.
  9. View The Latest Product References
  10. Deliyanti, D. & Wilkinson-Berka, J.L. (2015) Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.
    J Neuroinflammation. 12: 136.
  11. Simitzi, C. et al. (2015) Data in support on the shape of Schwann cells and sympathetic neurons onto microconically structured silicon surfaces.
    Data Brief. 4: 636-40.
  12. Dietrich, N. et al. (2016) The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy.
    PLoS One. 11 (12): e0167853.
  13. Uezumi, A. et al. (2021) Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.
    J Clin Invest. 131 (1): e139617.
  14. Wang, J. et al. (2020) CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair.
    Nat Commun. 11 (1): 4133.
  15. Warren, P.M. et al. (2020) Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries.
    Sci Rep. 10 (1): 11262.
  16. Piovesana, R. et al. (2020) Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells.
    Sci Rep. 10 (1): 7159.
  17. Castelnovo, L.F. et al. (2020) Membrane Progesterone Receptors (mPRs/PAQRs) Differently Regulate Migration, Proliferation, and Differentiation in Rat Schwann Cells.
    J Mol Neurosci. 70 (3): 433-48.
  18. De Vitis, E. et al. (2021) A microfabricated multi-compartment device for neuron and Schwann cell differentiation.
    Sci Rep. 11 (1): 7019.
  19. Ee, X. et al. (2017) Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within acellular nerve allografts.
    Biotechnol Bioeng. 114 (9): 2121-30.
  20. Ma, S. et al. (2021) Effect of papaverine on axonal outgrowth of primary retinal ganglion cells of Sprague Dawley rats.
    Exp Eye Res. 212: 108797.
  21. Salazar Intriago, M.S. et al. (2021) The Mechanisms Mediated by α7 Acetylcholine Nicotinic Receptors May Contribute to Peripheral Nerve Regeneration.
    Molecules.26(24):7668.
  22. Piovesana, R. et al. (2022) Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation.
    Biomolecules. 12 (2): 239.
  23. Botticelli, E. et al. (2022) Analysis of Signal Transduction Pathways Downstream M2 Receptor Activation: Effects on Schwann Cell Migration and Morphology
    Life. 12 (2): 211.
  24. Huang, J. et al. (2022) Schwann cells-derived Exosomes Promote Functional Recovery after Spinal Cord Injury by Promoting Angiogenesis
    Res Sq Jun 10 2022 [Epub ahead of print].

Synonyms
THY1
THY1.1
RRID
AB_322809
UniProt
P01830
Entrez Gene
Thy1
GO Terms
GO:0001525 angiogenesis
GO:0007010 cytoskeleton organization
GO:0005829 cytosol
GO:0005100 Rho GTPase activator activity
GO:0006469 negative regulation of protein kinase activity
GO:0016337 cell-cell adhesion
GO:0019901 protein kinase binding
GO:0030336 negative regulation of cell migration
GO:0030426 growth cone
GO:0034235 GPI anchor binding
GO:0043066 negative regulation of apoptosis
GO:0043547 positive regulation of GTPase activity
GO:0045576 mast cell activation
GO:0046549 retinal cone cell development
GO:0048041 focal adhesion assembly
GO:0048147 negative regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050771 negative regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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