CD61 antibody | HM beta 3.1



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F ResetHamster anti Mouse CD61:FITC
- Product Type
- Monoclonal Antibody
- Clone
- HM beta 3.1
- Isotype
- IgG
- Specificity
- CD61
Hamster anti Mouse CD61 antibody, clone HM beta 3-1 recognizes the murine integrin beta 3 subunit (CD61), a ~90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin. Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin (Yasuda et al. 1995). |
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
1% bovine serum albumin - Immunogen
- Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4.
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Spleen cells from immunized Armenian hamsters were fused with cells of the P3U1 mouse myeloma cell line.
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) FITC 490 525 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | ![]() |
Neat | 1/10 |
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Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Hamster (Armenian) IgG Negative Control:FITC | MCA2356F | F | 0.1 mg |
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Description | Hamster (Armenian) IgG Negative Control:FITC |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse Seroblock FcR | BUF041A | F | 0.1 mg |
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Description | Mouse Seroblock FcR | ||||||
Mouse Seroblock FcR | BUF041B | F | 0.5 mg |
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Description | Mouse Seroblock FcR |
Source Reference
-
Yasuda, M. et al. (1995) Expression and function of fibronectin binding integrins on rat mast cells.
Int Immunol. 7 (2): 251-8.
References for CD61 antibody
-
Hodkinson, P.S. et al. (2007) Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
J Biol Chem. 282 (39): 28991-9001. -
Moore, S.F. et al. (2015) Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.
Cardiovasc Res. 107 (1): 9-19. -
Raouf, J. et al. (2016) mPGES-1 deletion affects platelet functions in mice.
Clin Sci (Lond). Oct 07 [Epub ahead of print]. -
Kraft, S. et al. (2016) Identification and characterization of a unique role for EDB fibronectin in phagocytosis.
J Mol Med (Berl). 94 (5): 567-81. -
Ming, K.M. et al. (2015) Evaluation of the Genotoxicity of Eurycoma longifolia aqueous extract (PHYSTA®) using in vitro Ames Test and in vivo Mammalian Micronucleus Test.
Int J Pharm Pharmaceu Sci. 7 (8): 367-71.
- Synonyms
- Integrin Beta 3 Chain
- RRID
- AB_566860
- UniProt
- O54890
- Entrez Gene
- Itgb3
- GO Terms
- GO:0004872 receptor activity
- GO:0005178 integrin binding
- GO:0007044 cell-substrate junction assembly
- GO:0007160 cell-matrix adhesion
- GO:0007229 integrin-mediated signaling pathway
- GO:0007275 multicellular organismal development
- GO:0009897 external side of plasma membrane
MCA2299F

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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