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CD11b antibody | 5C6

Rat anti Mouse CD11b:FITC

Product Type
Monoclonal Antibody
Clone
5C6
Isotype
IgG2b
Specificity
CD11b

Product Code Applications Pack Size List Price Your Price Qty
MCA711FT
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F 25 µg loader
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loader
MCA711F
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F 0.1 mg loader
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loader

Rat anti Mouse CD11b antibody, clone 5C6 recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles.

Rat anti Mouse CD11b antibody, clone 5C6 immunoprecipitates a heterodimer of ~165 and ~95 kDa. This clone also exhibits various functional properties, reportedly inhibiting adhesion in vitro and inflammatory recruitment in vivo. Rat anti Mouse CD11b antibody, clone 5C6 also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes.
CiteAb logo - trusted, tested, published

Our CD11b (5C6) Antibody has been referenced in >161 publications*


*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Mouse
Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
1%Bovine Serum Albumin
Immunogen
Thioglycollate-elicited peritoneal macrophages (TPM)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Fusion Partners
Spleen cells from AO rats were fused with cells of the Y3 rat myeloma cell line
Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm)
FITC 490 525
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul.

The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR ( BUF041A/B).

How to Use the Spectraviewer

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Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse Seroblock FcR BUF041A F 0.1 mg loader
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Description Mouse Seroblock FcR
Mouse Seroblock FcR BUF041B F 0.5 mg loader
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Description Mouse Seroblock FcR

References for CD11b antibody

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  9. View The Latest Product References
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  80. Yoshizaki, S. et al. (2021) Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway.
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  81. Mañucat-Tan, N. et al. (2021) Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma.
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  84. Ji, N. et al. (2022) VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice.
    Neurotox Res. 40 (1): 78-88.
  85. Shanaki-Bavarsad, M. et al. (2022) Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI.
    Exp Neurobiol. 31 (3): 173-95.
  86. Bretheau, F. et al. (2022) The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury.
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  87. Bani-Hani, M. et al. (2023) Interactions of Carboxylated Nanodiamonds With Mouse Macrophages Cell Line and Primary Cells
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  88. Saraiva, C. et al. (2023) CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival.
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  89. Nelke, C. et al. (2023) K(2P)2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies.
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  90. Telianidis, J. et al. (2023) Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke.
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  91. Flocke, V. et al. (2023) Noninvasive assessment of metabolic turnover during inflammation by in vivo deuterium magnetic resonance spectroscopy.
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  92. Heiduschka, P. et al. (2023) Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of “Dry” Age-Related Macular Degeneration?
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  93. Lim, J. et al. (2018) Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages.
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  99. Maezawa, I. et al. (2018) Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.
    Brain. 141 (2): 596-612.
  100. Price, B.R. et al. (2020) Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition.
    J Neuroinflammation. 17 (1): 238.
  101. Thygesen, C. et al. (2018) Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease.
    Front Cell Neurosci. 12: 397.
  102. Weekman, E.M. et al. (2019) Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events.
    J Neuroinflammation. 16 (1): 284.
  103. Thei, L. et al. (2018) Extracellular signal-regulated kinase 2 has duality in function between neuronal and astrocyte expression following neonatal hypoxic-ischaemic cerebral injury.
    J Physiol. 596 (23): 6043-62.
  104. Ryan, F. et al. (2018) Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia.
    Front Neurosci. 12: 988.
  105. Rizzi, C. et al. (2018) NGF steers microglia toward a neuroprotective phenotype.
    Glia. 66 (7): 1395-416.
  106. Haight, E.S. et al. (2020) Of mice, microglia, and (wo)men: a case series and mechanistic investigation of hydroxychloroquine for complex regional pain syndrome.
    Pain Rep. 5 (5): e841.
  107. Berve, K. et al. (2020) Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.
    J Neuroinflammation. 17 (1): 323.
  108. Su, N. et al. (2023) Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of "Dry" Age-Related Macular Degeneration?
    Aging Dis. 14 (1): 184-203.
  109. Geladaris, A. et al. (2024) BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair.
    Acta Neuropathol. 147 (1): 75.
  110. Venezia, S. et al. (2021) Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.
    Parkinsonism Relat Disord. 91: 59-65.
  111. Klawonn, A.M. et al. (2021) Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons.
    Immunity. 54 (2): 225-234.e6.
  112. Wang, F. et al. (2021) Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain.
    Front Cell Neurosci. 15: 768059.
  113. Ryan, F. et al. (2024) Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury.
    Acta Neuropathol. 147 (1): 106.
  114. Zhao, Z. et al. (2020) A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration.
    J Neuroinflammation. 17 (1): 64.
  115. Schuhmann, M.K. et al. (2020) CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.
    Circ Res. 127 (8): 1023-1035.
  116. Flocke, V. et al. (2023) Noninvasive assessment of metabolic turnover during inflammation by in vivo deuterium magnetic resonance spectroscopy.
    Front Immunol. 14: 1258027.

Blocking Assay

Immunofluorescence

Immunohistology - Frozen

Synonyms
Integrin Alpha M Chain
MAC-1
RRID
AB_323464
UniProt
P05555
Entrez Gene
Itgam
GO Terms
GO:0001846 opsonin binding
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0005634 nucleus
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0030593 neutrophil chemotaxis
GO:0043395 heparan sulfate proteoglycan binding
GO:0045123 cellular extravasation
GO:0050798 activated T cell proliferation

MCA711FT

164960 1702

MCA711F

161633 162840 1801

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