VPS26A antibody | AB03/1G5

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Mouse anti VPS26A

Product Type
PrecisionAb Monoclonal
Clone
AB03/1G5
Isotype
IgG2b
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00920
Datasheet
WB
SDS
100 µl loader

Mouse anti VPS26A antibody recognizes vacuolar protein sorting-associated protein 26A, also known as VPS26.

VPS26A interacts with VPS35 and VPS29 and to form the retromer complex, involved in recycling proteins via retrograde transport from endosomes to the trans-Golgi network (Lucas et al. 2016). In mammals, the orthalog of VPS26A is VPS26B, and the exact role of each within the retromer complex is yet to be eluded. Correct retromer function is important for neuronal health, and defects appear to contribute to pathogenesis of Parkinson's Disease and Alzheimer's Disease (Reitz 2017). VPS26A also appears to be involved with regulating the stemness of embryonic stem cells during neurogenesis (Choi et al. 2018).

Product Details

Target Species
Human
Western Blotting
Mouse anti VPS26A detects a band of approximately 37 kDa in K562 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-327 of human VPS26A
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
O75436
Entrez Gene
VPS26A
GO Terms
GO:0005515 protein binding
GO:0005829 cytosol
GO:0007034 vacuolar transport
GO:0008565 protein transporter activity
GO:0010008 endosome membrane
GO:0030904 retromer complex
GO:0042147 retrograde transport, endosome to Golgi
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of VPS26A antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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