SYNTAXIN-1A antibody | RM367

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Rabbit anti SYNTAXIN-1A

Product Type
Monoclonal Antibody
Clone
RM367
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6353
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti syntaxin-1A antibody recognizes syntaxin-1A, also known as neuron-specific antigen HPC-1 and STX1A.

Syntaxin-1a is a SNARE protein, one of the central components of membrane fusion machinery (Liang et al. 2017). Membrane fusion is crucial for processes including intracellular transport, neurotransmitter release, and cell fertilization (Han et al. 2017). To mediate membrane fusion, the membrane SNARES syntaxin-1A and SNAP-25 form a heterodimer which can then offer a target site for the vesicle SNARE VAMP-2 (Fan et al. 2006). The two isoforms of syntaxin-1, A and B, have high homology. Overexpression of syntaxin-1A has been observed in primary brain tumors and colorectal, lung, and breast cancers (Raja et al. 2019). Syntaxin-1 has been suggested as a marker of neuroendocrine tumors (Kővári et al. 2020).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to residues near the N-terminus of human syntaxin-1A

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q16623
Entrez Gene
STX1A
GO Terms
GO:0016021 integral to membrane
GO:0005576 extracellular region
GO:0005484 SNAP receptor activity
GO:0006112 energy reserve metabolic process
GO:0006886 intracellular protein transport
GO:0050796 regulation of insulin secretion
GO:0014047 glutamate secretion
GO:0019717 synaptosome
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Regulatory
For research purposes only

Applications of SYNTAXIN-1A antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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