Rabbit anti syntaxin-1A antibody
recognizes syntaxin-1A, also known as neuron-specific antigen HPC-1 and STX1A.
Syntaxin-1a is a SNARE protein, one of the central components of membrane fusion machinery (Liang et al. 2017
). Membrane fusion is crucial for processes including intracellular transport, neurotransmitter release, and cell fertilization (Han et al. 2017
). To mediate membrane fusion, the membrane SNARES syntaxin-1A and SNAP-25 form a heterodimer which can then offer a target site for the vesicle SNARE VAMP-2 (Fan et al. 2006
). The two isoforms of syntaxin-1, A and B, have high homology. Overexpression of syntaxin-1A has been observed in primary brain tumors and colorectal, lung, and breast cancers (Raja et al. 2019
). Syntaxin-1 has been suggested as a marker of neuroendocrine tumors (Kővári et al. 2020
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of SYNTAXIN-1A antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.