SOX2 antibody | RM427
Rabbit anti SOX2
- Product Type
- Monoclonal Antibody
- Clone
- RM427
- Isotype
- IgG
- Specificity
- SOX2
Antibody Quality and Performance Guarantee
| Rabbit anti SOX2 antibody recognizes transcription factor SOX-2. SOX2 is a transcription factor which is essential for embryonic development. It helps maintain the stemness of embryonic cells and various adult stem cell populations. In conjunction with other co-factors, SOX2 enables the induction of pluripotent stem cells (iPSCs) from terminally differentiated somatic cells. Deletion of SOX2 in the vertebrate zygote leads to early embryonic lethality and malformation of the epiblast (Schaefer and Lengerke, 2020). SOX2 expression is dysregulated in a variety of human cancers, and actively contributes to cancer cell proliferation, migration, invasion and metastasis (Novak et al. 2020). In cancer, SOX2 levels appear optimized for tumor growth, where small changes in SOX2 expression would change tumor physiology. In addition, SOX2 appears to influence the response of tumor cells to oncology drugs (Wuebben and Rizzino, 2017). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of human SOX2
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/100 | 1/250 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P48431
- Entrez Gene
- SOX2
- GO Terms
- GO:0005515 protein binding
- GO:0001649 osteoblast differentiation
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005829 cytosol
- GO:0005667 transcription factor complex
- GO:0006325 chromatin organization
- GO:0007050 cell cycle arrest
- GO:0009611 response to wounding
- GO:0010843 promoter binding
- View More GO Terms
- GO:0021781 glial cell fate commitment
- GO:0035019 somatic stem cell maintenance
- GO:0035198 miRNA binding
- GO:0043281 regulation of caspase activity
- GO:0043410 positive regulation of MAPKKK cascade
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0050680 negative regulation of epithelial cell proliferation
- GO:0070848 response to growth factor stimulus
- GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
MCA6367
157630
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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