Rabbit anti SOX2 antibody
recognizes transcription factor SOX-2.
SOX2 is a transcription factor which is essential for embryonic development. It helps maintain the stemness of embryonic cells and various adult stem cell populations. In conjunction with other co-factors, SOX2 enables the induction of pluripotent stem cells (iPSCs) from terminally differentiated somatic cells. Deletion of SOX2 in the vertebrate zygote leads to early embryonic lethality and malformation of the epiblast (Schaefer and Lengerke, 2020
). SOX2 expression is dysregulated in a variety of human cancers, and actively contributes to cancer cell proliferation, migration, invasion and metastasis (Novak et al. 2020
). In cancer, SOX2 levels appear optimized for tumor growth, where small changes in SOX2 expression would change tumor physiology. In addition, SOX2 appears to influence the response of tumor cells to oncology drugs (Wuebben and Rizzino, 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human SOX2
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
sequence-specific DNA binding transcription factor activity
transcription factor complex
cell cycle arrest
response to wounding
glial cell fate commitment
somatic stem cell maintenance
regulation of caspase activity
positive regulation of MAPKKK cascade
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation
response to growth factor stimulus
negative regulation of canonical Wnt receptor signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of SOX2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
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