SETDB1 antibody

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Mouse anti SETDB1

SETDB1 antibody recognizes histone-lysine n-methyltransferase SETDB1, also known as ERG-associated protein with SET domain, ESET, H3-K9-HMTase 4, histone-lysine N-methyltransferase, H3lysine-9 specific 4, or lysine N-methyltransferase 1E.

Product Type
PrecisionAb™ Monoclonal
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VMA00243 WB 100 µl
Mouse anti Human SETDB1 antibody recognizes the histone-lysine N-methyltransferase SETDB1, also known as ERG-associated protein with SET domain, ERG-associated protein with a SET domain, ESET, H3-K9-HMTase 4, histone H3-K9 methyltransferase 4, histone-lysine N-methyltransferase SETDB1, histone-lysine N-methyltransferase, H3lysine-9 specific 4, lysine N-methyltransferase 1E and tudor domain containing 21.

Histone-lysine N-methyltransferase SETDB1 is a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. SETDB1 has been identified as a target for treatment in Huntington's disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of SETDB1 have been described (provided by RefSeq, Jun 2011).

Mouse anti Human SETDB1 antibody detects a band of 180 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Western Blotting
Anti SETDB1 detects a band of approximately 180 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Purified recombinant fragment of human SETDB1 expressed in E. coli
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
As supplied, 12 months from date of despatch.

More Information

Q15047 Related reagents
Entrez Gene
SETDB1 Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0006350 transcription
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0045449 regulation of transcription
PrecisionAb™ is a trademark of Bio-Rad Laboratories.
For research purposes only

Applications of SETDB1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P 2 ml WB
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