SETDB1 antibody

Mouse anti SETDB1

Product Type
PrecisionAb Monoclonal
Isotype
IgG1
Format
Purified
Specificity
SETDB1

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VMA00243
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WB 100 µl loader
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Mouse anti Human SETDB1 antibody recognizes the histone-lysine N-methyltransferase SETDB1, also known as ERG-associated protein with SET domain, ERG-associated protein with a SET domain, ESET, H3-K9-HMTase 4, histone H3-K9 methyltransferase 4, histone-lysine N-methyltransferase SETDB1, histone-lysine N-methyltransferase, H3lysine-9 specific 4, lysine N-methyltransferase 1E and tudor domain containing 21.

Histone-lysine N-methyltransferase SETDB1 is a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. SETDB1 has been identified as a target for treatment in Huntington's disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of SETDB1 have been described (provided by RefSeq, Jun 2011).

Mouse anti Human SETDB1 antibody detects a band of 180 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti SETDB1 detects a band of approximately 180 kDa in HEK293 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Purified recombinant fragment of human SETDB1 expressed in E. coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q15047
Entrez Gene
SETDB1
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0006350 transcription
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0045449 regulation of transcription
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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