RXR Alpha antibody | AB02/1D10

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Anti RXR Alpha Antibody, clone AB02/1D10 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti RXR Alpha Antibody, clone AB02/1D10 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with RXR alpha antibody (1/1000, **VMA00797**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to RXR alpha (molecular weight 58 kDa)

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Mouse anti RXR Alpha

Product Type: PrecisionAb Monoclonal
Clone: AB02/1D10
Isotype: IgG1
Format: Purified
Specificity: RXR Alpha

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00797 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti RXR alpha antibody recognizes retinoic acid receptor RXR-alpha, also known as NR2B1.

The retinoid X receptor (RXR) is part of the steroid/thyroid hormone superfamily of nuclear receptors, proteins which predominantly functions as transcription factors with roles in development, cell differentiation, metabolism, and cell death. RXR alpha is one of three known subtypes of RXR. RXR in general, and also RXR alpha are involved with cancer development. For example, a malfunction of RXR alpha is associated with liver cancer (Yamazaki et al. 2007). RXR is upregulated in several cancers, including many ductal breast carcinomas (Rodrigues de Almeida and Conda-Sheridan 2019). Targeting RXR alpha in breast cancer cell lines has been shown to inhibit proliferation, and caused disease regression in animal models (Crowe and Chandraratna 2004).

Target Species: Human
Western Blotting: Mouse anti RXR alpha antibody detects a band of approximately 58 kDa in HeLa cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-462 of human RXR alpha
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P19793
Entrez Gene: RXRA
GO Terms: GO:0000790 nuclear chromatin; GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0003706 ligand-regulated transcription factor activity; GO:0003707 steroid hormone receptor activity; GO:0003713 transcription coactivator activity; GO:0004886 retinoid-X receptor activity; GO:0005654 nucleoplasm; GO:0006766 vitamin metabolic process; GO:0008203 cholesterol metabolic process; View More GO Terms; GO:0008270 zinc ion binding; GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter; GO:0019899 enzyme binding; GO:0032526 response to retinoic acid; GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor; GO:0042809 vitamin D receptor binding; GO:0044255 cellular lipid metabolic process; GO:0044323 retinoic acid-responsive element binding; GO:0044419 interspecies interaction between organisms; GO:0046982 protein heterodimerization activity