PTPN11/6 antibody | CD01-3E11
Mouse anti Human PTPN11/6 antibody recognizes the tyrosine-protein phosphatase non-receptor type 11, also known as PTP-2C, protein-tyrosine phosphatase 1D, protein-tyrosine phosphatase 2C and tyrosine-protein phosphatase non-receptor type 11. This antibody has also been shown to recognize the tyrosine-protein phosphatase non-receptor type 6, also known as HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L and SHP1.
The proteins encoded by PTPN11 and the PTPN6 genes are members of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Mouse anti Human PTPN11/6 antibody detects a band of 68 kDa in whole cell lysates. The antibody has been extensively validated for western blotting.
The proteins encoded by PTPN11 and the PTPN6 genes are members of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Mouse anti Human PTPN11/6 antibody detects a band of 68 kDa in whole cell lysates. The antibody has been extensively validated for western blotting.
Product Details
- Target Species
- Human
- Western Blotting
- Anti PTPN11/6 detects a band of approximately 68 kDa in Jurkat cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli derived recombinant protein of human PTPN11
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q06124
- Entrez Gene
- PTPN11
- GO Terms
- GO:0005829 cytosol
- GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0007411 axon guidance
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0030168 platelet activation
- GO:0031295 T cell costimulation
- GO:0034329 cell junction assembly
- GO:0050900 leukocyte migration
- GO:0060333 interferon-gamma-mediated signaling pathway
- GO:0060334 regulation of interferon-gamma-mediated signaling pathway
- GO:0060337 type I interferon-mediated signaling pathway
- GO:0060338 regulation of type I interferon-mediated signaling pathway
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of PTPN11/6 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
