PIN1 antibody | 855CT1.7.5

Mouse anti PIN1

Product Type
PrecisionAb Monoclonal
Clone
855CT1.7.5
Isotype
IgG1
Format
Purified
Specificity
PIN1

Product Code Applications Pack Size List Price Your Price Qty
VMA00303
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
IP WB 100 µl loader
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Search for Batch Specific Datasheets

Mouse anti Human PIN1 antibody recognizes the peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also known as PPIase Pin1, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 and rotamase Pin1.

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Encoded by the PIN1 gene, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for PIN1 (provided by RefSeq, Jun 2011).

Mouse anti Human PIN1 antibody detects a band of 18 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti PIN1 detects a band of approximately 18 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Purified His-tagged PIN1 protein
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q13526
Entrez Gene
PIN1
GO Terms
GO:0006457 protein folding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005654 nucleoplasm
GO:0007049 cell cycle
GO:0007088 regulation of mitosis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032480 negative regulation of type I interferon production
GO:0050815 phosphoserine binding
GO:0050816 phosphothreonine binding
GO:0051443 positive regulation of ubiquitin-protein ligase activity
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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