PDIA6 antibody | CD02/1D11
siRNA Validated
Mouse anti PDIA6
- Product Type
- PrecisionAb Monoclonal
- Clone
- CD02/1D11
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- PDIA6
Antibody Quality and Performance Guarantee
| Mouse anti PDIA6 antibody recognizes protein disulfide-isomerase A6, also known as ER protein 5, TXNDC7. PDIA6 belongs to the protein disulfide isomerase (PDI) family. It functions as an oxidoreductase to catalyze the formation of disulfide bonds, and as a chaperone to assist with protein folding (Bai et al. 2019). PDIA6 is able to promote the proliferation and growth of many types of human cancer cell and plays important roles in tumor immunoevasion and proliferation (Gao et al. 2016). Overexpression of PDIA6 has been identified in patients with lung adenocarcinoma and correlates with clinical status (Tufo et al. 2014). PDIA6 also appears to have metabolic roles, having found to be essential for glucose-stimulated insulin secretion. When PDIA6 is ablated, insulin release is substantially inhibited (Eletto et al. 2016). |
|
- Target Species
- Human
- Western Blotting
- Mouse anti PDIA6 detects a band of approximately 50 kDa in HepG2 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-440 of human PDIA6
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q15084
- Entrez Gene
- PDIA6
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0006457 protein folding
- GO:0003756 protein disulfide isomerase activity
- GO:0005788 endoplasmic reticulum lumen
- GO:0005793 ER-Golgi intermediate compartment
- GO:0045454 cell redox homeostasis
- GO:0042470 melanosome
VMA00952
100005859
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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