Paxillin antibody | RM256
Rabbit anti Paxillin
- Product Type
- Monoclonal Antibody
- Clone
- RM256
- Isotype
- IgG
- Specificity
- Paxillin
Antibody Quality and Performance Guarantee
| Rabbit anti Human paxillin antibody recognizes paxillin (PXN). Paxillin is a scaffolding protein, and is a major component of focal adhesions (FAs) required for cell attachment, spreading, and migration. Paxillin is involved with recruiting specific kinases, phosphatases, cofactors, oncoproteins, and structural proteins with downstream roles in intracellular signaling pathways, leading to reorganization of the actin cytoskeleton (Lopez-Colome et al. 2017). The protein shows dynamic changes in expression via protein-protein interaction and phosphorylation. Abnormal paxillin expression correlates with tumor occurrence, invasion, and metastasis of some cancer types (Yang et al. 2017). Overexpression of paxillin has been identified in gastric cancer, prostate cancer, hepatocellular carcinoma, and colorectal carcinoma (Zhao et al. 2015). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the N-terminus of Human paxillin
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunocytochemistry |  |
1/1000 | 1/2000 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P49023
- Entrez Gene
- PXN
- GO Terms
- GO:0006936 muscle contraction
- GO:0005737 cytoplasm
- GO:0005875 microtubule associated complex
- GO:0005925 focal adhesion
- GO:0007160 cell-matrix adhesion
- GO:0007172 signal complex assembly
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0008013 beta-catenin binding
- GO:0008270 zinc ion binding
- View More GO Terms
- GO:0017166 vinculin binding
- GO:0030027 lamellipodium
- GO:0034329 cell junction assembly
- GO:0034614 cellular response to reactive oxygen species
MCA6310
155782
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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