Rabbit anti Human paxillin antibody
recognizes paxillin (PXN). Paxillin is a scaffolding protein, and is a major component of focal adhesions (FAs) required for cell attachment, spreading, and migration. Paxillin is involved with recruiting specific kinases, phosphatases, cofactors, oncoproteins, and structural proteins with downstream roles in intracellular signaling pathways, leading to reorganization of the actin cytoskeleton (Lopez-Colome et al. 2017
). The protein shows dynamic changes in expression via protein-protein interaction and phosphorylation. Abnormal paxillin expression correlates with tumor occurrence, invasion, and metastasis of some cancer types (Yang et al. 2017
). Overexpression of paxillin has been identified in gastric cancer, prostate cancer, hepatocellular carcinoma, and colorectal carcinoma (Zhao et al. 2015
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Paxillin antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.