PAICS antibody | OTI5B6
siRNA Validated
Filter by Application:
WB ResetMouse anti PAICS
- Product Type
- PrecisionAb Monoclonal
- Clone
- OTI5B6
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- PAICS
Antibody Quality and Performance Guarantee
| Mouse anti Human PAICS antibody, clone OTI5B6 recognizes PAICS, also known as AIR carboxylase, SAICAR synthetase, multifunctional protein ADE2 and multifunctional protein ADE2H1. The PAICS gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of PAICS. Multiple transcript variants encoding different isoforms have been found for PAICS (provided by RefSeq, Jul 2008). Mouse anti Human PAICS antibody, clone OTI5B6 detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
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- Target Species
- Human
- Western Blotting
- Anti PAICS detects a band of approximately 47 kDa in Raji cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography from ascites.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- Full length recombinant human PAICS (NP_006443) produced in HEK293T cells
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P22234
- Entrez Gene
- PAICS
- GO Terms
- GO:0005829 cytosol
- GO:0004638 phosphoribosylaminoimidazole carboxylase activity
- GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
- GO:0005524 ATP binding
- GO:0006189 'de novo' IMP biosynthetic process
- GO:0042802 identical protein binding
- GO:0009113 purine base biosynthetic process
VMA00207
240615
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