PAICS antibody | OTI5B6

Mouse anti PAICS

Product Type
PrecisionAb Monoclonal
Clone
OTI5B6
Isotype
IgG2b
Format
Purified
Specificity
PAICS

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VMA00207
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WB 100 µl loader
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Mouse anti Human PAICS antibody, clone OTI5B6 recognizes PAICS, also known as AIR carboxylase, SAICAR synthetase, multifunctional protein ADE2 and multifunctional protein ADE2H1.

The PAICS gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of PAICS. Multiple transcript variants encoding different isoforms have been found for PAICS (provided by RefSeq, Jul 2008).

Mouse anti Human PAICS antibody, clone OTI5B6 detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti PAICS detects a band of approximately 47 kDa in Raji cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant human PAICS (NP_006443) produced in HEK293T cells
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P22234
Entrez Gene
PAICS
GO Terms
GO:0005829 cytosol
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0006189 'de novo' IMP biosynthetic process
GO:0042802 identical protein binding
GO:0009113 purine base biosynthetic process
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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