Rabbit anti Human P90RSK1 (pThr359/pSer363) antibody
recognizes ribosomal protein S6 kinase alpha-1 (S6K-alpha-1), also known as RPS6KA1, RSK1, MAPKAPK1A when phosphorylated at threonine 359 and serine 363. P90RSK1 belongs to the RSK (ribosomal S6 kinase) family of serine/threonine kinases (Fisher and Blenis 1996
). P90RSK1 is a downstream effector of the Ras/ERK signalling pathway (Casalvieri et al. 2017
). It directly phosphorylates IkappaBbeta and activates NF-kappaB (Xu et al. 2006
). P90RSK1 has been reported to phosphorylate CREB on Ser133 (Cho et al. 2011
). RSK also promotes mTOR signaling and translation (Shahbazian et al. 2006
). Expression and activity of RSK1 promotes tumor growth and survival (Casalvieri et al. 2017
). Phosphorylation of P90RSK1, including at Thr359 and Ser363, activates P90RSK1 in the cytoplasm and at the plasma membrane, and fully active RSK1 localizes to the nucleus (Gao et al. 2012
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of P90RSK1 (pThr359/pSer363) antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.