P90RSK1 (pThr359/pSer363) antibody | RM233
Rabbit anti P90RSK1 (pThr359/pSer363)
- Product Type
- Monoclonal Antibody
- Clone
- RM233
- Isotype
- IgG
- Specificity
- P90RSK1 (pThr359/pSer363)
Antibody Quality and Performance Guarantee
| Rabbit anti Human P90RSK1 (pThr359/pSer363) antibody recognizes ribosomal protein S6 kinase alpha-1 (S6K-alpha-1), also known as RPS6KA1, RSK1, MAPKAPK1A when phosphorylated at threonine 359 and serine 363. P90RSK1 belongs to the RSK (ribosomal S6 kinase) family of serine/threonine kinases (Fisher and Blenis 1996). P90RSK1 is a downstream effector of the Ras/ERK signalling pathway (Casalvieri et al. 2017). It directly phosphorylates IkappaBbeta and activates NF-kappaB (Xu et al. 2006). P90RSK1 has been reported to phosphorylate CREB on Ser133 (Cho et al. 2011). RSK also promotes mTOR signaling and translation (Shahbazian et al. 2006). Expression and activity of RSK1 promotes tumor growth and survival (Casalvieri et al. 2017). Phosphorylation of P90RSK1, including at Thr359 and Ser363, activates P90RSK1 in the cytoplasm and at the plasma membrane, and fully active RSK1 localizes to the nucleus (Gao et al. 2012). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A phospho-peptide corresponding to Human P90RSK1 (pThr359/Ser363)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/200 | 1/500 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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|---|---|---|---|---|---|---|---|
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q15418
- Entrez Gene
- RPS6KA1
- GO Terms
- GO:0005515 protein binding
- GO:0000287 magnesium ion binding
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0005829 cytosol
- GO:0004674 protein serine/threonine kinase activity
- GO:0005524 ATP binding
- GO:0005654 nucleoplasm
- GO:0006468 protein phosphorylation
- View More GO Terms
- GO:0007268 synaptic transmission
- GO:0007411 axon guidance
- GO:0008063 Toll signaling pathway
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0045087 innate immune response
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051403 stress-activated MAPK cascade
MCA6299
155772
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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