Rabbit anti Human p63 antibody
recognizes tumor protein 63, also known as CUSP, KET, P63, P73H, P73L, TP73L. p63 is a transcription factor and important regulator of cell proliferation and survival. This protein plays a major role in maintenance and differentiation of stem cells, and is involved with epidermal development, heart development, and maintenance of female germ cells (Gonfloni et al. 2015
). p63 is involved with tumorigenesis, and is commonly linked with epithelial malignancies including squamous cancers (Galoczova et al. 2018
). Although p53, a close relative of 63, is frequently mutated in tumors, p53 is rarely mutated or deleted in cancer. Conflicting roles for p63 in cancer have been reported, with some studies showing oncogenic potential and other showing that p63 can function as a tumor suppressor (Inoue and Fry 2014
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of p63 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.