p40 (deltaNp63) antibody | RM392

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Rabbit anti p40 (deltaNp63)

Product Type
Monoclonal Antibody
Clone
RM392
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6358
Datasheet
P
SDS
0.1 ml loader

Rabbit anti p40 (deltaNp63) antibody recognizes tumor protein 63 (TP63), also known as p40, p51 and CUSP.

The transcription factor p63 belongs to the p53 gene family along with p53 and p73, which share a high level of homology and similar domain structures (Gonfloni et al. 2015). p63 is a key regulator of epidermal development. It has roles in stemness, cell cycle arrest, mobility and invasion and senescence, and multiple isoforms of p63 have diverse roles in cellular biology (Fisher et al. 2020). p63 is dysregulated in human cancers and affects chemosensitivity and chemoresistance (Melino 2011). Heterozygous mutations in the gene encoding p63 cause developmental disorders, often manifesting in skin abnormalities (Soares and Zhou 2018). The deltaNp63 isoform has been suggested to be highly specific for squamous/basal cells (Bishop et al. 2020), and it acts in a dominant negative way towards p53 (Geddert et al. 2003).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to human p40 (deltaNp63)

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q9H3D4�
Regulatory
For research purposes only

Applications of p40 (deltaNp63) antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/50 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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