p40 (deltaNp63) antibody | RM392
Rabbit anti p40 (deltaNp63)
- Product Type
- Monoclonal Antibody
- Clone
- RM392
- Isotype
- IgG
- Specificity
- p40 (deltaNp63)
Rabbit anti p40 (deltaNp63) antibody recognizes tumor protein 63 (TP63), also known as p40, p51 and CUSP. The transcription factor p63 belongs to the p53 gene family along with p53 and p73, which share a high level of homology and similar domain structures (Gonfloni et al. 2015). p63 is a key regulator of epidermal development. It has roles in stemness, cell cycle arrest, mobility and invasion and senescence, and multiple isoforms of p63 have diverse roles in cellular biology (Fisher et al. 2020). p63 is dysregulated in human cancers and affects chemosensitivity and chemoresistance (Melino 2011). Heterozygous mutations in the gene encoding p63 cause developmental disorders, often manifesting in skin abnormalities (Soares and Zhou 2018). The deltaNp63 isoform has been suggested to be highly specific for squamous/basal cells (Bishop et al. 2020), and it acts in a dominant negative way towards p53 (Geddert et al. 2003). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to human p40 (deltaNp63)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | 1/50 | 1/200 |
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- UniProt
- Q9H3D4�
MCA6358
157621If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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