p38 MAPK antibody | RM245
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WB P ResetRabbit anti p38 MAPK
- Product Type
- Monoclonal Antibody
- Clone
- RM245
- Isotype
- IgG
- Specificity
- p38 MAPK
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| Rabbit anti Human MAPK14 antibody recognizes mitogen-activated protein kinase 14, also known as p38alpha, CSBP, MXI2, SAPK2A. MAPK14 is a member of th p38 MAP kinase (MAPK) family, and is a stress-activated serine/threonine protein kinase involved with inflammation. MAPK14 is activated in response to extracellular stress and helps regulate transcription and translation of specific genes, allowing a cell to fine-tune its response. Within the immune system, MAPK14 promotes production of pro-inflammatory cytokines from macrophages, and helps determine the strength and duration of the inflammatory response (Alam and Scheper 2016). MAPK14 is able to regulate a diverse range of biological processes, including cell proliferation, differentiation, apoptosis, senescence, and inflammation (Wu et al. 2019). In colon cancer, MAPK14 has been shown to be required for cell proliferation and survival, and its inhibition leads to cell cycle arrest and autophagy-mediated cell death (Paillas et al. 2012). MAPK14 inhibition has been suggested as a treatment for several inflammatory diseases, including Chron's disease and rheumatoid arthritis (She et al. 2018). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Expected from Sequence Mouse Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to Human p38 MAPK
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/1000 | 1/5000 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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- UniProt
- Q16539
- P53778
- Entrez Gene
- MAPK12
- MAPK14
- GO Terms
- GO:0005515 protein binding
- GO:0000287 magnesium ion binding
- GO:0005739 mitochondrion
- GO:0004707 MAP kinase activity
- GO:0005524 ATP binding
- GO:0005654 nucleoplasm
- GO:0006975 DNA damage induced protein phosphorylation
- GO:0007050 cell cycle arrest
- GO:0007265 Ras protein signal transduction
- View More GO Terms
- GO:0007517 muscle organ development
- GO:0045445 myoblast differentiation
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051149 positive regulation of muscle cell differentiation
- GO:0000187 activation of MAPK activity
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0005829 cytosol
- GO:0004708 MAP kinase kinase activity
- GO:0006928 cellular component movement
- GO:0006935 chemotaxis
- GO:0008063 Toll signaling pathway
- GO:0010670 positive regulation of oxygen and reactive oxygen species metabolic process
- GO:0016071 mRNA metabolic process
- GO:0030168 platelet activation
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0042692 muscle cell differentiation
- GO:0042770 signal transduction in response to DNA damage
- GO:0045087 innate immune response
- GO:0051090 regulation of transcription factor activity
- GO:0051403 stress-activated MAPK cascade
- GO:0071479 cellular response to ionizing radiation
- GO:0090400 stress-induced premature senescence
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