NFkB p105/p50 antibody | RM299
Rabbit anti NFkB p105/p50
- Product Type
- Monoclonal Antibody
- Clone
- RM299
- Isotype
- IgG
- Specificity
- NFkB p105/p50
Rabbit anti Human NFKB p105/p50 antibody recognizes nuclear factor NF-kappa-B p105 subunit, also known as NFKB1, DNA-binding factor KBF1, EBP-1. NFKB is a transcription factor divided into a family of subunits. NFKB1 is synthesized as a longer precursor protein (p105) that can be proteolytically cleaved into a shorter, DNA-binding form (p50) which can bind other NFKB subunits and elicit a variety of transcriptional responses. p65:p50 heterodimers activate the NFKB response and drive inflammation, whereas p50:p50 homodimers are critical suppressors of the NFKB response (Cartwright et al. 2016). Dysregulated NFKB signaling is strongly associated with carcinogenesis, and NFKB1 can either act as a tumor promoter or suppressor depending on its interactions. p65:p50 hoterodimers are generally pro-inflammatory and pro-tumorigenic, whereas p50:p50 homodimers can have a tumor suppressive effect (Concetti and Wilson 2018). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Expected from Sequence Mouse Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to residues in Human NF?B p105/p50
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | 1/100 | 1/200 | |
Western Blotting | 1/100 | 1/200 |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
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Description | Sheep anti Rabbit IgG:RPE |
- UniProt
- P19838
- Entrez Gene
- NFKB1
- GO Terms
- GO:0005515 protein binding
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0006915 apoptosis
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005654 nucleoplasm
- GO:0006366 transcription from RNA polymerase II promoter
- View More GO Terms
- GO:0006916 anti-apoptosis
- GO:0006954 inflammatory response
- GO:0008063 Toll signaling pathway
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010744 positive regulation of macrophage derived foam cell differentiation
- GO:0010843 promoter binding
- GO:0010884 positive regulation of lipid storage
- GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
- GO:0010957 negative regulation of vitamin D biosynthetic process
- GO:0016563 transcription activator activity
- GO:0031293 membrane protein intracellular domain proteolysis
- GO:0032269 negative regulation of cellular protein metabolic process
- GO:0032375 negative regulation of cholesterol transport
- GO:0033256 I-kappaB/NF-kappaB complex
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0045087 innate immune response
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050852 T cell receptor signaling pathway
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
MCA6326
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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