Rabbit anti NeuN antibody
recognizes RNA binding protein fox-1 homolog 3 (RBFOX3), also known as fox-1 homolog C.
NeuN is a neuronal nuclear RNA-binding protein, localized in the nuclei and perinuclear cytoplasm of most neurons in the mammalian central nervous system (Gusel’nikova and Korzhevskiy, 2015
). NeuN is a regulator of neuronal splicing and is involved with neurogenesis and synaptogenesis. It regulates differentiation of neurons by alternative splicing of Numb. Dysfunctions in NeuN have been identified associated with neurodevelopmental disorders including epilepsy, speech disorders and autism (Lin et al. 2018
). Accordingly, a role for NeuN has been suggested in human neurological function, and proteins regulated by NeuN have been suggested as therapeutic targets for treatment of NeuN-linked neurological disorders (Wang et al. 2015
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the N-terminus of human NeuN
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Neun antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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