Neun antibody | RM312

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Rabbit anti Neun

Product Type
Monoclonal Antibody
Clone
RM312
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6344
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti NeuN antibody recognizes RNA binding protein fox-1 homolog 3 (RBFOX3), also known as fox-1 homolog C.

NeuN is a neuronal nuclear RNA-binding protein, localized in the nuclei and perinuclear cytoplasm of most neurons in the mammalian central nervous system (Gusel’nikova and Korzhevskiy, 2015). NeuN is a regulator of neuronal splicing and is involved with neurogenesis and synaptogenesis. It regulates differentiation of neurons by alternative splicing of Numb. Dysfunctions in NeuN have been identified associated with neurodevelopmental disorders including epilepsy, speech disorders and autism (Lin et al. 2018). Accordingly, a role for NeuN has been suggested in human neurological function, and proteins regulated by NeuN have been suggested as therapeutic targets for treatment of NeuN-linked neurological disorders (Wang et al. 2015).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of human NeuN

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
A6NFN3
Entrez Gene
RBFOX3
GO Terms
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Regulatory
For research purposes only

Applications of Neun antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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