MSH3 antibody | RM405

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Rabbit anti MSH3

Product Type
Monoclonal Antibody
Clone
RM405
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6363
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti MSH3 antibody recognizes DNA mismatch repair protein Msh3, also known as DUP and MRP1.

MSH3 is a DNA mismatch repair protein essential for CAG.CTG repeat expansion. It is a genetic modifier of somatic instability in myotonic dystrophy type 1 (DM1) and progression in Huntington's disease (Flower et al. 2019). Mismatch repair is one of the most important DNA repair processes, correcting errors introduced during DNA replication and contributing to apoptotic signaling (Yang et al. 2018). Deficiency in MSH3 results in suppressed homologous recombination, and MSH3 frequently undergoes somatic mutation in mismatch repair-deficient cancers (Takahashi et al. 2011).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to residues near the N-terminus of human MSH3

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P20585
Entrez Gene
MSH3
GO Terms
GO:0000228 nuclear chromosome
GO:0000403 Y-form DNA binding
GO:0000404 loop DNA binding
GO:0000406 double-strand/single-strand DNA junction binding
GO:0000710 meiotic mismatch repair
GO:0005524 ATP binding
GO:0007131 reciprocal meiotic recombination
GO:0008094 DNA-dependent ATPase activity
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019899 enzyme binding
GO:0032302 MutSbeta complex
GO:0043570 maintenance of DNA repeat elements
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
Regulatory
For research purposes only

Applications of MSH3 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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