Rabbit anti MSH3 antibody
recognizes DNA mismatch repair protein Msh3, also known as DUP and MRP1.
MSH3 is a DNA mismatch repair protein essential for CAG.CTG repeat expansion. It is a genetic modifier of somatic instability in myotonic dystrophy type 1 (DM1) and progression in Huntington's disease (Flower et al. 2019
). Mismatch repair is one of the most important DNA repair processes, correcting errors introduced during DNA replication and contributing to apoptotic signaling (Yang et al. 2018
). Deficiency in MSH3 results in suppressed homologous recombination, and MSH3 frequently undergoes somatic mutation in mismatch repair-deficient cancers (Takahashi et al. 2011
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to residues near the N-terminus of human MSH3
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
Y-form DNA binding
loop DNA binding
double-strand/single-strand DNA junction binding
meiotic mismatch repair
reciprocal meiotic recombination
DNA-dependent ATPase activity
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
negative regulation of DNA recombination
positive regulation of helicase activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of MSH3 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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