Lysosome Membrane Protein 2 antibody

Mouse anti Lysosome Membrane Protein 2

Product Type
PrecisionAb Monoclonal
Isotype
IgG2b
Format
Purified
Specificity
Lysosome Membrane Protein 2

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VMA00074
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Mouse anti Human lysosome membrane protein 2 antibody recognizes lysosome membrane protein 2, also known as 85 kDa lysosomal membrane sialoglycoprotein, LGP85, CD36 antigen-like 2, SCARB2, LIMP II and scavenger receptor class B member 2.

Lysosome membrane protein 2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Human LIMP2 is a ubiquitously expressed protein involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in lysosome membrane protein 2 caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for SCARB2 (provided by RefSeq, Feb 2011).

Mouse anti Human lysosome membrane protein 2 antibody detects a band of 80 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti lysosome membrane protein 2 detects a band of approximately 80 kDa in LNCaP cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E. Coli derived recombinant protein, aa249-478 of human lysosome membrane protein 2
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q14108
Entrez Gene
SCARB2
GO Terms
GO:0005515 protein binding
GO:0007155 cell adhesion
GO:0004872 receptor activity
GO:0005887 integral to plasma membrane
GO:0005624 membrane fraction
GO:0005765 lysosomal membrane
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