Lrpprc antibody | AB02/2F11
siRNA Validated
IP-MS Validated
Mouse anti Lrpprc
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB02/2F11
- Isotype
- IgG1
- Format
- Purified
- Specificity
- Lrpprc
Antibody Quality and Performance Guarantee
| Mouse anti LRPPRC antibody recognizes leucine-rich PPR motif-containing protein, mitochondrial, also known as LRP130. LRPPRC is a member of the pentatricopeptide repeat (PPR) family, a group of proteins which play major roles in RNA stability, regulation, processing, splicing, translation, and editing. LRPPRC is a multifunctional protein involved with mitochondrial gene expression and function, cell cycle progression, and tumorigenesis (Li et al. 2014). It can be found localized to the nuclear membrane, nucleoplasm, endoplasmic reticulum, cytoskeleton, and mitochondria, and carries out its roles by direct or indirect interaction with other proteins (Cui et al. 2019). LRPPRC has been found to be overexpressed in a variety of human cancers including lung adenocarcinoma, oesophageal squamous cell carcinoma, stomach, colon, mammary and endometrial adenocarcinoma, and lymphoma. These findings are consistent with observations that LRPPRC can suppress autophagy and mitophagy (Jiang et al. 2014). |
|
- Target Species
- Human
- Western Blotting
- Mouse anti LRPPRC detects a band of approximately 146 kDa in K562 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 611-907 of human LRPPRC
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation |  |
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| Western Blotting | |
1/10000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P42704
- Entrez Gene
- LRPPRC
- GO Terms
- GO:0000794 condensed nuclear chromosome
- GO:0003723 RNA binding
- GO:0005637 nuclear inner membrane
- GO:0005640 nuclear outer membrane
- GO:0005654 nucleoplasm
- GO:0005856 cytoskeleton
- GO:0006350 transcription
- GO:0008017 microtubule binding
- GO:0042645 mitochondrial nucleoid
- View More GO Terms
- GO:0045449 regulation of transcription
- GO:0047497 mitochondrion transport along microtubule
- GO:0048471 perinuclear region of cytoplasm
- GO:0048487 beta-tubulin binding
- GO:0051028 mRNA transport
VMA00967
100005803
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