Lrpprc antibody | AB02/2F11

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Mouse anti Lrpprc

Product Type
PrecisionAb Monoclonal
Clone
AB02/2F11
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00967
Datasheet
IP WB
SDS
100 µl loader

Mouse anti LRPPRC antibody recognizes leucine-rich PPR motif-containing protein, mitochondrial, also known as LRP130. LRPPRC is a member of the pentatricopeptide repeat (PPR) family, a group of proteins which play major roles in RNA stability, regulation, processing, splicing, translation, and editing. LRPPRC is a multifunctional protein involved with mitochondrial gene expression and function, cell cycle progression, and tumorigenesis (Li et al. 2014). It can be found localized to the nuclear membrane, nucleoplasm, endoplasmic reticulum, cytoskeleton, and mitochondria, and carries out its roles by direct or indirect interaction with other proteins (Cui et al. 2019). LRPPRC has been found to be overexpressed in a variety of human cancers including lung adenocarcinoma, oesophageal squamous cell carcinoma, stomach, colon, mammary and endometrial adenocarcinoma, and lymphoma. These findings are consistent with observations that LRPPRC can suppress autophagy and mitophagy (Jiang et al. 2014).

Product Details

Target Species
Human
Western Blotting
Mouse anti LRPPRC detects a band of approximately 146 kDa in K562 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 611-907 of human LRPPRC
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
P42704
Entrez Gene
LRPPRC
GO Terms
GO:0000794 condensed nuclear chromosome
GO:0003723 RNA binding
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005856 cytoskeleton
GO:0006350 transcription
GO:0008017 microtubule binding
GO:0042645 mitochondrial nucleoid
GO:0045449 regulation of transcription
GO:0047497 mitochondrion transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0051028 mRNA transport
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of Lrpprc antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/10000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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