IL-1 Beta antibody | AbD52287ia

Human anti Interleukin-1 beta (Canakinumab Biosimilar)

Product Type
Monoclonal Antibody
Clone
AbD52287ia
Isotype
IgG1
Specificity
IL-1 Beta

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New MCA6405
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SDS Safety Datasheet SDS
E 0.2 mg loader
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Human Anti Interleukin-1β antibody, clone AbD52287ia is a research grade biosimilar of the monoclonal antibody drug canakinumab. It is a recombinant human IgG1 kappa antibody of the allotype G1m3. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.

Human Anti IL-1β antibody, clone AbD52287ia, is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-canakinumab antibodies.

Canakinumab is a recombinant human monoclonal antibody which binds to IL-1β (interleukin-1 beta). It’s mode of action is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation in patients with disorders of autoimmune origin. In June 2009, the FDA approved canakinumab for the treatment of cryopyrin-associated periodic syndromes (CAPS), a spectrum of autoinflammatory syndromes. In September 2016, the FDA approved it’s use for three additional rare and serious auto-inflammatory diseases: tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), and familial Mediterranean fever (FMF). In June 2020, canakinumab was FDA-approved for the indication to treat active Still's disease, including adult-onset Still's disease (AOSD).

This product is NOT FOR THERAPEUTIC USE.

Target Species
Human
Product Form
Human IgG1 antibody selected from the HuCAL® phage display library and expressed in a mammalian cell line. This antibody is supplied as a liquid.
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.01% Thiomersal
Immunogen
Human IL-1β
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Protocols and further information may be found in the HuCAL Technical Manual

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Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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