GNL3 antibody | AB03/2F7
Mouse anti GNL3
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB03/2F7
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- GNL3
Mouse anti GNL3 antibody recognizes guanine nucleotide-binding protein-like 3, also known as NNP47, E2IG3, NS, and nucleostemin. Nucleostemin is a nucleolar protein, but rapidly shuttles between the nucleolar and nucleoplasmic compartments when bound to GTP, and this shuttling is regulated by multiple control mechanisms (Kavyasudha et al. 2018). It appears to play a role in protecting DNA damage, both on the telomeres and non-telomeric regions of the chromosomes. It is highly expressed in various types of stem cells, tumors, and cancer stem cells, and is expressed at a much lower level in differentiated cells (Tsai et al. 2014), appearing to play a role in the cell cycle and proliferation of rapidly-dividing cells (Kavyasudha et al. 2018). Accordingly, nucleostemin contributes to formation of blastocysts, embryogenesis, regeneration of postnatal tissue, reprogramming of cells to pluripotency, and cancer development (Tsai et al. 2014). Nucleostemin is highly expressed in a wide variety of cancers, and could serve as a marker for tumor progression and poor patient outcome (Sami et al. 2019). |
- Target Species
- Human
- Western Blotting
- Mouse anti GNL3 antibody detects a band of approximately 65 kDa in HEK293 cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-226 of human GNL3
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Goat anti Mouse IgG (H/L):HRP |
- UniProt
- Q9BVP2
- Entrez Gene
- GNL3
- GO Terms
- GO:0005515 protein binding
- GO:0005525 GTP binding
- GO:0005730 nucleolus
- GO:0042127 regulation of cell proliferation
VMA00887
100004572If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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