Gnaq antibody | CD02/1H5

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Mouse anti Gnaq

Product Type
PrecisionAb Monoclonal
Clone
CD02/1H5
Isotype
IgG2a
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00912
Datasheet
WB
SDS
100 µl loader

Mouse anti GNAQ antibody recognizes guanine nucleotide-binding protein G(q) subunit alpha, also known as GAQ.

GNAQ encodes an alpha subunit of G proteins, which control ion channels to transmit signals across cell membranes (Inanobe and Kurachi 2014). GNAQ is involved in the endothelin signaling pathway and regulates the migration of melanoblasts in the dermis during development (Urtatiz and Raamsdonk 2016). GNAQ is an oncogene for uveal melanoma, for which there are no effective therapies (Feng et al. 2019).

Product Details

Target Species
Human
Western Blotting
Mouse anti GNAQ detects a band of approximately 41 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-359 of human GNAQ
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
P50148
Entrez Gene
GNAQ
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0006469 negative regulation of protein kinase activity
GO:0006471 protein ADP-ribosylation
GO:0050821 protein stabilization
GO:0030168 platelet activation
GO:0035412 regulation of catenin import into nucleus
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of Gnaq antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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