GMNN antibody

Mouse anti GMNN

Product Type
PrecisionAb Monoclonal
Isotype
IgG1
Format
Purified
Specificity
GMNN

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VMA00332
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SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human GMNN antibody recognizes geminin.

Encoded by the GMNN gene, geminin plays a critical role in cell cycle regulation, inhibiting DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. Geminin is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of GMNN may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for GMNN, and two pseudogenes of GMNN are located on the short arm of chromosome 16 (provided by RefSeq, Oct 2011).

Mouse anti Human GMNN antibody detects a band of 30 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti GMNN detects a band of approximately 30 kDa in K562 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Recombinant human GMNN
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
O75496
Entrez Gene
GMNN
GO Terms
GO:0000216 M/G1 transition of mitotic cell cycle
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0008156 negative regulation of DNA replication
GO:0016564 transcription repressor activity
GO:0032582 negative regulation of gene-specific transcription
GO:0042826 histone deacetylase binding
GO:0045786 negative regulation of cell cycle
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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