GMNN antibody

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Anti GMNN Antibody (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with GMNN antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 31.4 second exposure. Arrow points to GMNN (molecular weight 30 kDa)

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Mouse anti GMNN

Product Type: PrecisionAb Monoclonal
Isotype: IgG1
Format: Purified
Specificity: GMNN

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VMA00332 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human GMNN antibody recognizes geminin.

Encoded by the GMNN gene, geminin plays a critical role in cell cycle regulation, inhibiting DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. Geminin is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of GMNN may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for GMNN, and two pseudogenes of GMNN are located on the short arm of chromosome 16 (provided by RefSeq, Oct 2011).

Mouse anti Human GMNN antibody detects a band of 30 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti GMNN detects a band of approximately 30 kDa in K562 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: Recombinant human GMNN
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: O75496
Entrez Gene: GMNN
GO Terms: GO:0000216 M/G1 transition of mitotic cell cycle; GO:0005829 cytosol; GO:0005654 nucleoplasm; GO:0008156 negative regulation of DNA replication; GO:0016564 transcription repressor activity; GO:0032582 negative regulation of gene-specific transcription; GO:0042826 histone deacetylase binding; GO:0045786 negative regulation of cell cycle