Rabbit anti Human glutamate receptor 1 (pSer845) antibody recognizes glutamate receptor 1, also known as GRIA1, GLUA1, GLUR1, when phosphorylated at serine 845. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate brain, and glutamate binding to glutamate receptors leads to activation of downstream neurons (Zhu and Gouaux 2018). The GRIA gene encodes a subunit of the ionotropic glutamate receptor (iGluRs), a ligand-gated ion channel which regulates neuronal excitability at the synaptic cleft (Yu and Lau 2017). Disrupted functions of glutamergic synapses are common in many cognitive and neuropsychiatric disorders, leading to imbalances between neuronal excitation and inhibition. Consistent with this, iGluRs have emerged as potential drug targets for szhizophrenia, depression, and addiction (Reiner and Levitz 2019). Polymorphisms in GRIA1 appears to be a migraine-related gene (Gao and Wang 2018). Glutamate receptor 1 appears to play a role in mediating the growth and progression of triple-negative breast cancer, and also appears to play a role in melanoma (Speyer et al. 2014). Phosphorylation of glutamate receptor 1 at serine 845 is involved in AMPA receptor trafficking (Lee et al. 2000).

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin		1/500	1/1000
Western Blotting		1/1000	1/2000