Glutamate Receptor 1 (pSer845) antibody | RM296

Rabbit anti Glutamate Receptor 1 (pSer845)

Product Type
Monoclonal Antibody
Clone
RM296
Isotype
IgG
Specificity
Glutamate Receptor 1 (pSer845)

Product Code Applications Pack Size List Price Your Price Qty
MCA6324
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SDS Safety Datasheet SDS
P WB 0.1 ml loader
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Rabbit anti Human glutamate receptor 1 (pSer845) antibody recognizes glutamate receptor 1, also known as GRIA1, GLUA1, GLUR1, when phosphorylated at serine 845. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate brain, and glutamate binding to glutamate receptors leads to activation of downstream neurons (Zhu and Gouaux 2018). The GRIA gene encodes a subunit of the ionotropic glutamate receptor (iGluRs), a ligand-gated ion channel which regulates neuronal excitability at the synaptic cleft (Yu and Lau 2017). Disrupted functions of glutamergic synapses are common in many cognitive and neuropsychiatric disorders, leading to imbalances between neuronal excitation and inhibition. Consistent with this, iGluRs have emerged as potential drug targets for szhizophrenia, depression, and addiction (Reiner and Levitz 2019). Polymorphisms in GRIA1 appears to be a migraine-related gene (Gao and Wang 2018). Glutamate receptor 1 appears to play a role in mediating the growth and progression of triple-negative breast cancer, and also appears to play a role in melanoma (Speyer et al. 2014). Phosphorylation of glutamate receptor 1 at serine 845 is involved in AMPA receptor trafficking (Lee et al. 2000).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A phospho-peptide corresponding to Human glutamate receptor 1 (pSer845)
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P42261
Entrez Gene
GRIA1
GO Terms
GO:0016021 integral to membrane
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005789 endoplasmic reticulum membrane
GO:0007268 synaptic transmission
GO:0015277 kainate selective glutamate receptor activity
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0045211 postsynaptic membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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