Glutamate Receptor 1 (pSer845) antibody | RM296
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WB ResetRabbit anti Glutamate Receptor 1 (pSer845)
- Product Type
- Monoclonal Antibody
- Clone
- RM296
- Isotype
- IgG
- Specificity
- Glutamate Receptor 1 (pSer845)
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| Rabbit anti Human glutamate receptor 1 (pSer845) antibody recognizes glutamate receptor 1, also known as GRIA1, GLUA1, GLUR1, when phosphorylated at serine 845. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate brain, and glutamate binding to glutamate receptors leads to activation of downstream neurons (Zhu and Gouaux 2018). The GRIA gene encodes a subunit of the ionotropic glutamate receptor (iGluRs), a ligand-gated ion channel which regulates neuronal excitability at the synaptic cleft (Yu and Lau 2017). Disrupted functions of glutamergic synapses are common in many cognitive and neuropsychiatric disorders, leading to imbalances between neuronal excitation and inhibition. Consistent with this, iGluRs have emerged as potential drug targets for szhizophrenia, depression, and addiction (Reiner and Levitz 2019). Polymorphisms in GRIA1 appears to be a migraine-related gene (Gao and Wang 2018). Glutamate receptor 1 appears to play a role in mediating the growth and progression of triple-negative breast cancer, and also appears to play a role in melanoma (Speyer et al. 2014). Phosphorylation of glutamate receptor 1 at serine 845 is involved in AMPA receptor trafficking (Lee et al. 2000). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A phospho-peptide corresponding to Human glutamate receptor 1 (pSer845)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/500 | 1/1000 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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- UniProt
- P42261
- Entrez Gene
- GRIA1
- GO Terms
- GO:0016021 integral to membrane
- GO:0005234 extracellular-glutamate-gated ion channel activity
- GO:0005789 endoplasmic reticulum membrane
- GO:0007268 synaptic transmission
- GO:0015277 kainate selective glutamate receptor activity
- GO:0030054 cell junction
- GO:0030666 endocytic vesicle membrane
- GO:0045211 postsynaptic membrane
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