Flii antibody | AB01/1C12

Mouse anti Flii

Product Type
PrecisionAb Monoclonal
Clone
AB01/1C12
Isotype
IgG1
Format
Purified
Specificity
Flii

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VMA00888
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IP WB 100 µl loader
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Mouse anti FLII antibody recognizes protein flightless-1 homolog, also known as FLIL.

FLII is a member of the actin-remodelling gelsolin protein superfamily. The protein plays a role in cell migration, co-localizing with small GTPases in actin-rich structures at the leading edge of motile cells, and interacting directly with Ras (Marei et al. 2016). FLII is involved with skin development, formation of tight junctions, and skin recovery after injury. Overexpression of FLII appears to contribute to inflammatory skin conditions, such as psoriasiform dermatitis and atopic dermatitis, and inhibition of FLII has been suggested as a potential therapy (Kopecki et al. 2018). FLII interacts with a variety of proteins involved with cell signaling, and appears to regulate activity of multiple transcription factors. It acts as a tumor suppressor in prostate cancer (Wang et al. 2016), promotes progression of breast cancer by impeding selective autophagy (He et al. 2018), and is implicated in colorectal cancer, hepatocellular carcinoma, and lung cancer (Wang et al. 2017).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti FLII antibody detects a band of approximately 148 kDa in HEK293 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 801-1269 of human FLII
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q13045
Entrez Gene
FLII
GO Terms
GO:0006936 muscle contraction
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005813 centrosome
GO:0006350 transcription
GO:0007275 multicellular organismal development
GO:0045449 regulation of transcription
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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