Flii antibody | AB01/1C12
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|Mouse anti FLII antibody recognizes protein flightless-1 homolog, also known as FLIL.
FLII is a member of the actin-remodelling gelsolin protein superfamily. The protein plays a role in cell migration, co-localizing with small GTPases in actin-rich structures at the leading edge of motile cells, and interacting directly with Ras (Marei et al. 2016). FLII is involved with skin development, formation of tight junctions, and skin recovery after injury. Overexpression of FLII appears to contribute to inflammatory skin conditions, such as psoriasiform dermatitis and atopic dermatitis, and inhibition of FLII has been suggested as a potential therapy (Kopecki et al. 2018). FLII interacts with a variety of proteins involved with cell signaling, and appears to regulate activity of multiple transcription factors. It acts as a tumor suppressor in prostate cancer (Wang et al. 2016), promotes progression of breast cancer by impeding selective autophagy (He et al. 2018), and is implicated in colorectal cancer, hepatocellular carcinoma, and lung cancer (Wang et al. 2017).
- Target Species
- Western Blotting
- Mouse anti FLII antibody detects a band of approximately 148 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- E. coli-derived recombinant protein of amino acids 801-1269 of human FLII
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- For research purposes only
- 12 months from date of despatch
- PrecisionAb is a trademark of Bio-Rad Laboratories
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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