Flii antibody | AB01/1C12
IP-MS Validated
Mouse anti Flii
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB01/1C12
- Isotype
- IgG1
- Format
- Purified
- Specificity
- Flii
Antibody Quality and Performance Guarantee
| Mouse anti FLII antibody recognizes protein flightless-1 homolog, also known as FLIL. FLII is a member of the actin-remodelling gelsolin protein superfamily. The protein plays a role in cell migration, co-localizing with small GTPases in actin-rich structures at the leading edge of motile cells, and interacting directly with Ras (Marei et al. 2016). FLII is involved with skin development, formation of tight junctions, and skin recovery after injury. Overexpression of FLII appears to contribute to inflammatory skin conditions, such as psoriasiform dermatitis and atopic dermatitis, and inhibition of FLII has been suggested as a potential therapy (Kopecki et al. 2018). FLII interacts with a variety of proteins involved with cell signaling, and appears to regulate activity of multiple transcription factors. It acts as a tumor suppressor in prostate cancer (Wang et al. 2016), promotes progression of breast cancer by impeding selective autophagy (He et al. 2018), and is implicated in colorectal cancer, hepatocellular carcinoma, and lung cancer (Wang et al. 2017). |
|
- Target Species
- Human
- Western Blotting
- Mouse anti FLII antibody detects a band of approximately 148 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 801-1269 of human FLII
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation |  |
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| Western Blotting | |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q13045
- Entrez Gene
- FLII
- GO Terms
- GO:0006936 muscle contraction
- GO:0003779 actin binding
- GO:0005634 nucleus
- GO:0005813 centrosome
- GO:0006350 transcription
- GO:0007275 multicellular organismal development
- GO:0045449 regulation of transcription
VMA00888
100004233
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