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ErbB2 antibody | RM228

Rabbit anti ErbB2

Product Type
Monoclonal Antibody
Clone
RM228
Isotype
IgG
Specificity
ErbB2

Product Code Applications Pack Size List Price Your Price Qty
MCA6298
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P WB 0.1 ml loader
List Price Your Price
loader

Rabbit anti Human ErbB2 antibody recognizes receptor tyrosine-protein kinase erbB-2, also known as HER2, MLN19, NEU, NGL. The protein HER2, encoded by the ErbB2 gene, is a transmembrane glycoprotein which belongs to the epidermal growth factor receptor (EGFR)/HER1 family. The ErbB receptors carry out essential functions of development and tissue maintenance, but loss of regulation underlies many diseases (Wieduwilt and Moasser 2008). ErbB2 is an oncogene and is amplified or overexpressed in many human malignancies, including approximately 30% of human breast cancers, and ErbB2-overexpressing tumors appear to predict a poor clinical outcome (Yu and Hung 2000). Anti-HER2 drugs are used to treat HER2+ breast cancers, but drug resistance remains a challenge (Liu et al. 2020).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of ErbB2
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/400
Western Blotting 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P04626
Entrez Gene
ERBB2
GO Terms
GO:0003677 DNA binding
GO:0016021 integral to membrane
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005006 epidermal growth factor receptor activity
GO:0043125 ErbB-3 class receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0006350 transcription
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008283 cell proliferation
GO:0042802 identical protein binding
GO:0014065 phosphatidylinositol 3-kinase cascade
GO:0019903 protein phosphatase binding
GO:0048015 phosphatidylinositol-mediated signaling
GO:0042060 wound healing
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0045449 regulation of transcription
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0050679 positive regulation of epithelial cell proliferation

MCA6298

155771

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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