EIF3H antibody | AB04/3F5
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|Mouse anti EIF3H antibody recognizes eukaryotic translation initiation factor 3 subunit H, also known as EIF3S3.
EIF3H is a subunit of the mammalian EIF3 complex, and contributes to mRNA recruitment and ribosomal complex disassembly. EIF3H was found to be involved with regulation of cell growth and viability, which led to the suggestion that it could provide a growth advantage to cancer cells (Savinainen et al. 2006). Accordingly, it has been identified as a known driver of cell proliferation and survival in cancer, overexpressed in prostate, breast, and liver cancer, and has been associated with poor prognosis (Cappuzzo et al. 2009). EIF3H knockdown can lead to apoptosis of colorectal cancer cells, leading to its suggestion as a potential biomarker (Yu et al. 2018).
- Target Species
- Western Blotting
- Mouse anti EIF3H detects a band of approximately 40 kDa in HeLa cell lysates
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- E. coli-derived recombinant protein of amino acids 1-352 of human EIF3H
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- For research purposes only
- 12 months from date of despatch
- PrecisionAb is a trademark of Bio-Rad Laboratories
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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