EIF3G antibody | AB05/3H10

Mouse anti EIF3G

Product Type
PrecisionAb Monoclonal
Clone
AB05/3H10
Isotype
IgG1
Format
Purified
Specificity
EIF3G

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VMA00934
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti EIF3G antibody recognizes eukaryotic translation initiation factor 3 subunit G, also known as EIF3S4.

EIF3G is a subunit of the mammalian EIF3 complex, and is involved with translation reinitiation and protein synthesis (Kim et al. 2013). Roles for EIF3G have been identified in the cytoskeletal network (Burnicka-Turek et al. 2010) and in caspase-mediated apoptosis (Kim et al. 2013). EIF3G appears to play roles in cancer development, and clues have included its nuclear distribution in breast cancer cells (Zheng et al. 2016) and overexpression in an adriamycin-resistant erythroleukemia cell line (Zhu et al. 2009). It has also been suggested that EIF3G could be a target for managing chemoresistance in patients with colorectal cancer (Yang et al. 2018). A single nucleotide polymorphism is associated with risk of narcolepsy (Holm et al. 2015).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti EIF3G detects a band of approximately 42 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-320 of human EIF3G
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
O75821
Entrez Gene
EIF3G
GO Terms
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0003743 translation initiation factor activity
GO:0005829 cytosol
GO:0005634 nucleus
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0048471 perinuclear region of cytoplasm
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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