Rabbit anti Human EGF Receptor antibody
recognizes epidermal growth factor receptor (EGFR), also known as ERBB, ERBB1, HER1. EGFR is a 1210 amino acid single pass type 1 ~170 kDa transmembrane glycoprotein and is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut (Wee and Wang 2017
). EGFR also plays roles in regulation of autophagy and metabolism following cellular or environmental stress (Sigismund et al. 2018
). Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon (Garcia de Palazzo et al. 1993
), and in diverse cancer types, EGFR overexpression is associated with a poor prognosis. Cancer therapies targeting EGFR can include monoclonal antibodies, tyrosine kinase inhibitors, PI3K inhibitors, and antisense gene therapy (Xu et al. 2018
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of EGF R antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.