EGF R antibody | RM294

Rabbit anti EGF Receptor

Product Type
Monoclonal Antibody
Clone
RM294
Isotype
IgG
Specificity
EGF R

Product Code Applications Pack Size List Price Your Price Qty
MCA6323
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SDS Safety Datasheet SDS
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Rabbit anti Human EGF Receptor antibody recognizes epidermal growth factor receptor (EGFR), also known as ERBB, ERBB1, HER1. EGFR is a 1210 amino acid single pass type 1 ~170 kDa transmembrane glycoprotein and is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut (Wee and Wang 2017). EGFR also plays roles in regulation of autophagy and metabolism following cellular or environmental stress (Sigismund et al. 2018). Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon (Garcia de Palazzo et al. 1993), and in diverse cancer types, EGFR overexpression is associated with a poor prognosis. Cancer therapies targeting EGFR can include monoclonal antibodies, tyrosine kinase inhibitors, PI3K inhibitors, and antisense gene therapy (Xu et al. 2018).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of Human EGF Receptor
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/200 1/500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P00533
Entrez Gene
EGFR
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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