CPS1 antibody | RM395

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Rabbit anti CPS1

Product Type
Monoclonal Antibody
Clone
RM395
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6360
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti CPS1 antibody recognizes carbamoyis a multidomain mitochondrial enzyme which l-phosphate synthase [ammonia], mitochondrial, also known as CPSase I.

CPS1 is a multidomain mitochondrial enzyme which produces carbamoyl phosphate (CP) from ammonia and bicarbonate and initiates disposal of nitrogen (Kim et al. 2017). CPS1 is the rate-limiting enzyme in the first step of the urea cycle, and is crucial for correct human liver metabolism. It is involved with arginine and pyrimidine metabolism (Çeliktaş et al. 2017). CPS1 is involved with liver diseases such as hepatitis C (HCV) and hepatic fibrosis (Wu et al. 2020). It is expressed mostly in intestinal epithelial cells and liver cells, but is also expressed in many cancer types including liver, colorectal, stomach, cervical, and pancreatic cancer (Çeliktaş et al. 2017). Accordingly, CPS1 is involved with the occurrence and development of malignancies (Wu et al. 2020).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of human CPS1 (Carbamoyl-Phosphate Synthase). This antibody may also react to mouse or rat CPS1, as predicted by immunogen homology.

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P31327
Entrez Gene
CPS1
GO Terms
GO:0000050 urea cycle
GO:0004087 carbamoyl-phosphate synthase (ammonia) activity
GO:0005524 ATP binding
GO:0005980 glycogen catabolic process
GO:0006541 glutamine metabolic process
GO:0045909 positive regulation of vasodilation
GO:0019240 citrulline biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0032496 response to lipopolysaccharide
GO:0042645 mitochondrial nucleoid
GO:0046209 nitric oxide metabolic process
GO:0070409 carbamoyl phosphate biosynthetic process
Regulatory
For research purposes only

Applications of CPS1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/5000 1/10000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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