Cofilin 1 antibody | 25C1-E3-D3
Mouse anti Cofilin 1
- Product Type
- PrecisionAb Monoclonal
- Clone
- 25C1-E3-D3
- Isotype
- IgG2a
- Format
- Purified
- Specificity
- Cofilin 1
Antibody Quality and Performance Guarantee
| Mouse anti Human cofilin 1 antibody recognizes CFL1, also known as HEL-S-15. The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus (supplied by OMIM, Apr 2004). Mouse anti Human cofilin 1 antibody detects a band of 18 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
|
- Target Species
- Human
- Western Blotting
- Mouse anti cofilin 1 antibody detects a band of approximately 18 kDa in HEK293 cells
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant human cofilin 1 (aa 1-166)
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
- UniProt
- P23528
- Entrez Gene
- CFL1
- GO Terms
- GO:0002576 platelet degranulation
- GO:0003779 actin binding
- GO:0009615 response to virus
- GO:0006916 anti-apoptosis
- GO:0007266 Rho protein signal transduction
- GO:0007411 axon guidance
- GO:0016363 nuclear matrix
- GO:0030168 platelet activation
VMA00870
158259
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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