Rabbit anti CDKN2A antibody
recognizes cyclin-dependent kinase inhibitor 2A, also known as CDK4I, MTS-1 and p16-INK4.
CDKN2A activation prevents carcinogenesis by activating senescence and arrest of cell growth. As such, it is upregulated in cellular senescence and functions as a tumor suppressor in a range of human cancers including colorectal cancer (Xing et al. 2013
). CDKN2A inhibits the cell cycle proteins cyclin-dependent kinase 4 (CDK4) and CDK6. Loss of CDKN2A function can result in uncontrolled proliferation and neoplastic transformation (Shima et al. 2011
). CDKN2A often undergoes DNA hypermethylation in cancer, including colon cancer. This hypermethylation at the promoter region leads to silencing of the gene encoding CDKN2A and may lead to development, progression, and invasion of colorectal cancer (Xing et al. 2013
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human CDKN2A
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
cell cycle checkpoint
G1 phase of mitotic cell cycle
G1/S transition of mitotic cell cycle
negative regulation of cell-matrix adhesion
cyclin-dependent protein kinase inhibitor activity
induction of apoptosis
cell cycle arrest
Ras protein signal transduction
negative regulation of cell proliferation
protein kinase binding
negative regulation of cell growth
negative regulation of NF-kappaB transcription factor activity
positive regulation of smooth muscle cell apoptosis
negative regulation of cyclin-dependent protein kinase activity
positive regulation of macrophage apoptosis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CDKN2A antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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