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CDKN2A antibody | RM409

Rabbit anti CDKN2A

Product Type
Monoclonal Antibody

Product Code Applications Pack Size List Price Your Price Qty
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P WB 0.1 ml loader
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Rabbit anti CDKN2A antibody recognizes cyclin-dependent kinase inhibitor 2A, also known as CDK4I, MTS-1 and p16-INK4.

CDKN2A activation prevents carcinogenesis by activating senescence and arrest of cell growth. As such, it is upregulated in cellular senescence and functions as a tumor suppressor in a range of human cancers including colorectal cancer (Xing et al. 2013). CDKN2A inhibits the cell cycle proteins cyclin-dependent kinase 4 (CDK4) and CDK6. Loss of CDKN2A function can result in uncontrolled proliferation and neoplastic transformation (Shima et al. 2011). CDKN2A often undergoes DNA hypermethylation in cancer, including colon cancer. This hypermethylation at the promoter region leads to silencing of the gene encoding CDKN2A and may lead to development, progression, and invasion of colorectal cancer (Xing et al. 2013).

Target Species
Product Form
Purified IgG - liquid
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
A peptide corresponding to the C-terminus of human CDKN2A
For research purposes only
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Entrez Gene
GO Terms
GO:0000075 cell cycle checkpoint
GO:0000080 G1 phase of mitotic cell cycle
GO:0000082 G1/S transition of mitotic cell cycle
GO:0005515 protein binding
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005829 cytosol
GO:0004861 cyclin-dependent protein kinase inhibitor activity
GO:0005634 nucleus
GO:0006917 induction of apoptosis
GO:0007050 cell cycle arrest
GO:0007265 Ras protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0019901 protein kinase binding
GO:0030308 negative regulation of cell growth
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034393 positive regulation of smooth muscle cell apoptosis
GO:0045736 negative regulation of cyclin-dependent protein kinase activity
GO:0051059 NF-kappaB binding
GO:0090399 replicative senescence
GO:2000111 positive regulation of macrophage apoptosis



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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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