CDK13 antibody | 46B7-G7

Mouse anti CDK13

Product Type
PrecisionAb Monoclonal
Clone
46B7-G7
Isotype
IgG2b
Format
Purified
Specificity
CDK13

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Mouse anti Human CDK13 antibody recognizes cyclin-dependent kinase 13 (CDK13), otherwise known as CRK7 and CRKRS

CDK13 is a member of the CDK family of serine/threonine protein kinases which can be divided into two groups, those that regulate the cell cycle and those that regulate transcription (Paculová and Kohoutek 2017). CDK13 is a regulator of transcription, and can upregulate the expression of genes involved with responses to DNA damage, stress, and heat shock (Lui et al. 2018). CDK proteins bind to cyclin subunits to activate their functions. CDK13, like CDK12, forms a complex with cyclin K to regulate several cellular processes (Kohoutek and Blazek 2012). Aberrant levels of CDK13 have been associated with several cancers, including hepatocellular carcinoma (HCC) and colorectal cancer, and may affect tumor progression (Dong et al. 2018). Targeting CDK13 have been suggested as a treatment for MYC-dependent ovarian cancers (Zeng et al. 2018).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti CDK13 detects a band of approximately 192 kDa in HEK293 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
A peptide corresponding to amino acid 1391-1415 of CDK13
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C. avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

UniProt
Q14004
Entrez Gene
CDK13
GO Terms
GO:0004693 cyclin-dependent protein kinase activity
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0007088 regulation of mitosis
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation

VMA00875

158349

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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