CDK12 antibody | 45F7-H2
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|Mouse anti Human CDK12 antibody recognizes cyclin-dependent kinase 12 (CDK12), otherwise known as CrkRS and CRK7
CDK12 is a member of the CDK family of serine/threonine protein kinases which can be divided into two groups, those that regulate the cell cycle and those that regulate transcription (Paculová and Kohoutek 2017). CDK12 is a regulator of transcription, and can upregulate the expression of genes involved with responses to DNA damage, stress, and heat shock (Lui et al. 2018). CDK proteins bind to cyclin subunits to activate their functions. CDK12, like CDK13, forms a complex with cyclin K to regulate several cellular processes (Kohoutek and Blazek 2012). Genomic alterations in CDK12 have been identified with a frequency of 5 to 15% in various cancer types including esophageal, stomach, breast, endometrial, uterine, ovarian, bladder, colorectal, and pancreatic cancers. CDK12 inhibition has been suggested as a target to slow cancer growth (Lui et al. 2018).
- Target Species
- Western Blotting
- Mouse anti CDK12 detects a band of approximately 203 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Mouse monoclonal antibody affinity purified on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- A peptide corresponding to amino acid 479-508 of CDK12
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
- PrecisionAb is a trademark of Bio-Rad Laboratories.
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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