CD66e antibody | RM326

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Rabbit anti CD66e

Product Type
Monoclonal Antibody
Clone
RM326
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6346
Datasheet
E P WB
SDS
0.1 ml loader

Rabbit anti CD66e antibody recognizes carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CEA.

CD66e is a fetal glycoprotein which is normally expressed by mucosal cells and is not usually highly expressed after birth. However, CD66e can be expressed in a number of disease states including colorectal cancer (CRC) (Hall et al. 2019) and cancers of the breast, liver, stomach, and pancreas. It is therefore considered to be a classic tumor marker. A number of benign conditions can also lead to elevations in CD66e expression including hypothyroidism and pancreatitis, but expression level is generally lower than in cancer (Asad-Ur-Rahman and Saif 2016). High Cd66e expression in the serum of patients with cancer is related to tumor deterioration and subclinical metastases (Wan et al. 2019).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Native CD66e protein purified from human liver tissue

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P06731
Entrez Gene
CEACAM5
GO Terms
GO:0005887 integral to plasma membrane
GO:0031225 anchored to membrane
GO:0016323 basolateral plasma membrane
Regulatory
For research purposes only

Applications of CD66e antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000 1/5000
Immunohistology - Paraffin 1/1000 1/2000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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