Rabbit anti Human CD279 antibody recognizes programmed cell death protein 1 (PDCD1), also known as PD1. CD279 is a transmembrane protein expressed in immune cells such as T, B, and NK cells (Arasanz et al. 2017). The protein has an immunosuppressive effect during T cell activation, and regulates effector functions during acute and chronic infection, cancer and autoimmunity. In this way, CD279 plays an important role in balancing protective immunity and immunopathology (Sharpe and Pauken. 2017). Cancer immunotherapies that target CD279 aim to restore correct T cell function, allowing T cells to eliminate infections and cancer (Nguyen and Ohashi 2014). Antibodies which specifically block CD279 are approved in multiple countries for melanoma and for non-small cell lung cancer, among other cancer types (Iwai et al. 2017).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the N-terminus of Human CD279
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
protein tyrosine phosphatase activity
signal transducer activity
humoral immune response
multicellular organismal development
T cell costimulation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD279 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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