CD279 antibody | RM309

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Rabbit anti CD279

Product Type
Monoclonal Antibody
Clone
RM309
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6330
Datasheet
P WB
SDS
0.1 ml loader

Rabbit anti Human CD279 antibody recognizes programmed cell death protein 1 (PDCD1), also known as PD1. CD279 is a transmembrane protein expressed in immune cells such as T, B, and NK cells (Arasanz et al. 2017). The protein has an immunosuppressive effect during T cell activation, and regulates effector functions during acute and chronic infection, cancer and autoimmunity. In this way, CD279 plays an important role in balancing protective immunity and immunopathology (Sharpe and Pauken. 2017). Cancer immunotherapies that target CD279 aim to restore correct T cell function, allowing T cells to eliminate infections and cancer (Nguyen and Ohashi 2014). Antibodies which specifically block CD279 are approved in multiple countries for melanoma and for non-small cell lung cancer, among other cancer types (Iwai et al. 2017).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of Human CD279

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Guarantee
12 months from date of despatch

More Information

UniProt
Q15116
Entrez Gene
PDCD1
GO Terms
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0004725 protein tyrosine phosphatase activity
GO:0004871 signal transducer activity
GO:0006959 humoral immune response
GO:0007275 multicellular organismal development
GO:0031295 T cell costimulation
Regulatory
For research purposes only

Applications of CD279 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/200 1/500
Western Blotting 1/100 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader

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