Rabbit anti CD278 antibody
recognizes inducible T-cell costimulator, also known as ICOS and AILIM.
CD278 is a member of the immunoglobulin family of co-receptor molecules mainly expressed on activated cytotoxic T cells, memory T cells, and regulatory T cells (Xiao et al. 2020
). Its main role appears to be supporting differentiation and function of CD4+ follicular helper (Tfh) cells during germinal centre reactions (Panneton et al. 2018
). The protein has significant homology to CD28 and CTLA-4. CD278 expression is induced on T cells following T cell receptor (TCR) cross-linking and/or CD28 co-stimulation (Wikenheiser and Stumhofer 2016
). Because of its expression pattern, CD278 provides an early and sensitive method for detecting T-cell immune responses to cancer therapy (Xiao et al. 2020
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human CD278
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
T cell costimulation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD278 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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