CD278 antibody | RM417

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Rabbit anti CD278

Product Type
Monoclonal Antibody
Clone
RM417
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6368
Datasheet
P
SDS
0.1 ml loader

Rabbit anti CD278 antibody recognizes inducible T-cell costimulator, also known as ICOS and AILIM.

CD278 is a member of the immunoglobulin family of co-receptor molecules mainly expressed on activated cytotoxic T cells, memory T cells, and regulatory T cells (Xiao et al. 2020). Its main role appears to be supporting differentiation and function of CD4+ follicular helper (Tfh) cells during germinal centre reactions (Panneton et al. 2018). The protein has significant homology to CD28 and CTLA-4. CD278 expression is induced on T cells following T cell receptor (TCR) cross-linking and/or CD28 co-stimulation (Wikenheiser and Stumhofer 2016). Because of its expression pattern, CD278 provides an early and sensitive method for detecting T-cell immune responses to cancer therapy (Xiao et al. 2020).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of human CD278

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q9Y6W8
Entrez Gene
ICOS
GO Terms
GO:0005576 extracellular region
GO:0006955 immune response
GO:0031295 T cell costimulation
Regulatory
For research purposes only

Applications of CD278 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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