CD274 antibody | RM320
Rabbit anti CD274
- Product Type
- Monoclonal Antibody
- Clone
- RM320
- Isotype
- IgG
- Specificity
- CD274
Antibody Quality and Performance Guarantee
| Rabbit anti Human CD274 antibody recognizes programmed cell death 1 ligand 1 (PD-L1), also known as B7-H1. CD274 is a cell-surface glycoprotein induced by cytokines, importantly interferon gamma from T helper cells under inflammatory conditions (Inaguma et al. 2017). CD274 is expressed in a range of tissues, but mostly in activated T and B lymphocyte cells, dendritic cells, and monocytes (Fabrizio et al. 2018). CD274 is an inhibitory immune checkpoint inhibitor which plays a role in maintaining peripheral T-lymphocyte tolerance and regulating inflammation (Schutz et al. 2017). Constitutive upregulation of CD274 has been identified in solid tumors (Franzen et al. 2017), and expression of CD274 in the tumor microenvironment appears to be one of the main mechanisms in which cancer can evade the immune system via inhibiting anti-tumor T-cell immunity (Zou et al. 2016). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of Human CD274
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunocytochemistry |  |
1/200 | 1/500 |
| Immunohistology - Paraffin | |
1/200 | 1/1000 |
| Western Blotting | |
1/500 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q9EP73
- Entrez Gene
- Cd274
- GO Terms
- GO:0005515 protein binding
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
- GO:0009897 external side of plasma membrane
- GO:0042130 negative regulation of T cell proliferation
MCA6329
155799
167465
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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