Rabbit anti CD20 antibody
recognizes B-lymphocyte antigen CD20, also known as Bp35 and MS4A1.
CD20 is a non-glycosylated protein expressed on the surface of B lymphocytes and consisting of four hydrophobic transmembrane domains (Pavlasova and Mraz 2020
). CD20 is involved with the regulation of transmembrane Ca2+ conductance, and is also involved with cell cycle progression during human B cell proliferation and activation (Payandeh et al. 2018
). Deficiencies of CD20 have been shown to produce attenuated antibody production and germinal centre formation. Owing to its structure and expression pattern, CD20 is an important therapeutic target. Therapeutic antibodies against CD20 have revolutionized treatment of B cell haematological malignancies. Anti-CD20 antibodies also play roles in the treatment of inflammatory and autoimmune diseases (Casan et al. 2018
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human CD20
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to plasma membrane
B cell activation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD20 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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