Catalase antibody | OTI1B6

Mouse anti Catalase

Product Type
PrecisionAb Monoclonal
Clone
OTI1B6
Isotype
IgG1
Format
Purified
Specificity
Catalase

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VMA00129
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Mouse anti Human catalase antibody, clone OTI1B6 recognizes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress.

Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. It converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in the CAT gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by catalase (provided by RefSeq, Oct 2009).

Mouse anti Human catalase antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti catalase detects a band of approximately 60 kDa in K562 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant human catalase (NP_111743) produced in HEK293T cells
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P04040
Entrez Gene
CAT
GO Terms
GO:0004096 catalase activity
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0006144 purine base metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0009650 UV protection
GO:0020037 heme binding
GO:0042744 hydrogen peroxide catabolic process
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptosis
GO:0050661 NADP binding
GO:0051262 protein tetramerization
GO:0051781 positive regulation of cell division
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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