Rabbit anti Human calponin 1 antibody
recognizes calponin 1, also known as CCN1, basic calponin, Calponin H1, smooth muscle. Calponin 1 mostly expressed in abundance in smooth muscle cells (Liu and Jin 2016
). It is a stress fiber-associated protein which co-localizes and stabilizes actin, and regulates contractility in smooth muscle (Ciuba et al. 2018
). Decreased levels of calponin-1 may be involved with early hypertension via matrix metalloproteinase-2 (MMP-2) (Belo et al. 2016
) Calponin 1 and calponin 2 have been suggested as novel targets for treatment of hypertension (Feng et al. 2020
). Calponin 1 appears to function as a tumor suppressor (Mitchell et al. 2020), and has been identified as a protective factor in melanoma, ovarian cancer, renal angiomyolipoma and colon cancer (Qiu et al. 2017
). Calponin 1 can also help distinguish benign from invasive breast carcinomas (Mitchell et al. 2020
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Calponin 1 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.