Calponin 1 antibody | RM262

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Rabbit anti Calponin 1

Product Type
Monoclonal Antibody
Clone
RM262
Isotype
IgG
Product Code Applications Pack Size List Price Quantity
MCA6309
Datasheet
IC WB
SDS
0.1 ml loader

Rabbit anti Human calponin 1 antibody recognizes calponin 1, also known as CCN1, basic calponin, Calponin H1, smooth muscle. Calponin 1 mostly expressed in abundance in smooth muscle cells (Liu and Jin 2016). It is a stress fiber-associated protein which co-localizes and stabilizes actin, and regulates contractility in smooth muscle (Ciuba et al. 2018). Decreased levels of calponin-1 may be involved with early hypertension via matrix metalloproteinase-2 (MMP-2) (Belo et al. 2016) Calponin 1 and calponin 2 have been suggested as novel targets for treatment of hypertension (Feng et al. 2020). Calponin 1 appears to function as a tumor suppressor (Mitchell et al. 2020), and has been identified as a protective factor in melanoma, ovarian cancer, renal angiomyolipoma and colon cancer (Qiu et al. 2017). Calponin 1 can also help distinguish benign from invasive breast carcinomas (Mitchell et al. 2020).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the C-terminus of Human calponin-1

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Guarantee
12 months from date of despatch

More Information

UniProt
P51911
Entrez Gene
CNN1
GO Terms
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005856 cytoskeleton
GO:0006940 regulation of smooth muscle contraction
GO:0031032 actomyosin structure organization
Regulatory
For research purposes only

Applications of Calponin 1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunocytochemistry 1/100 1/200
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

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