Calponin 1 antibody | RM262
Rabbit anti Calponin 1
- Product Type
- Monoclonal Antibody
- Clone
- RM262
- Isotype
- IgG
- Specificity
- Calponin 1
Rabbit anti Human calponin 1 antibody recognizes calponin 1, also known as CCN1, basic calponin, Calponin H1, smooth muscle. Calponin 1 mostly expressed in abundance in smooth muscle cells (Liu and Jin 2016). It is a stress fiber-associated protein which co-localizes and stabilizes actin, and regulates contractility in smooth muscle (Ciuba et al. 2018). Decreased levels of calponin-1 may be involved with early hypertension via matrix metalloproteinase-2 (MMP-2) (Belo et al. 2016) Calponin 1 and calponin 2 have been suggested as novel targets for treatment of hypertension (Feng et al. 2020). Calponin 1 appears to function as a tumor suppressor (Mitchell et al. 2020), and has been identified as a protective factor in melanoma, ovarian cancer, renal angiomyolipoma and colon cancer (Qiu et al. 2017). Calponin 1 can also help distinguish benign from invasive breast carcinomas (Mitchell et al. 2020). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of Human calponin-1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunocytochemistry | 1/100 | 1/200 | |
Western Blotting | 1/1000 | 1/2000 |
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Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
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Description | Sheep anti Rabbit IgG:RPE |
- UniProt
- P51911
- Entrez Gene
- CNN1
- GO Terms
- GO:0003779 actin binding
- GO:0005516 calmodulin binding
- GO:0005856 cytoskeleton
- GO:0006940 regulation of smooth muscle contraction
- GO:0031032 actomyosin structure organization
MCA6309
155781If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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