CALD1 antibody | RM396
Rabbit anti CALD1
- Product Type
- Monoclonal Antibody
- Clone
- RM396
- Isotype
- IgG
- Specificity
- CALD1
Antibody Quality and Performance Guarantee
| Rabbit anti CALD1 antibody recognizes caldesmon, also known as CDM and CAD. CALD1 is an actin-binding protein which is also able to bind myosin, calmodulin and tropomyosin, and inhibits the actin-activated myosin ATPase by blockin actin-myosin interaction. As a "side-binder" of actin, CALD1 stabilizes the filamentous structure of actin and is therefore profoundly involved with assembly and organization of the actin cytoskeleton (Wang 2008). CALD1 negatively regulates cell proliferation and migration and release of metalloproteinase, and is itself regulated by a range of kinases at multiple phosphorylation sites (Hai 2015). It is found in smooth muscle and non-muscle cells. In smooth muscle, CALD1 appears to regulate smooth muscle contraction and cell motility (Eves et al. 2006). CALD1 has been observed to be downregulated in many cancer cell types and has been identified as a potent suppressor of cell invasion, regulating podosome/invadopodium formation of cancer cells (Yoshio et al. 2007). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the C-terminus of human CALD1. This antibody may also react to mouse or rat CALD1, as predicted by immunogen homology
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/100 | 1/200 |
| Western Blotting | |
1/100 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q05682
- Entrez Gene
- CALD1
- GO Terms
- GO:0006936 muscle contraction
- GO:0003779 actin binding
- GO:0005829 cytosol
- GO:0005516 calmodulin binding
- GO:0005523 tropomyosin binding
- GO:0005925 focal adhesion
- GO:0006928 cellular component movement
- GO:0017022 myosin binding
- GO:0030016 myofibril
- View More GO Terms
MCA6361
157624
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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