Braf antibody | RM308
Rabbit anti Braf
- Product Type
- Monoclonal Antibody
- Clone
- RM308
- Isotype
- IgG
- Specificity
- Braf
Antibody Quality and Performance Guarantee
| Rabbit anti Human BRAF antibody recognizes serine/threonine-protein kinase B-raf, also known as p94, RAFB1. BRAF is a serine-threonine kinase activated by Ras (Ascierto et al. 2012). BRAF activates the MAP kinase / ERK signaling pathway, which results in activation of transcription factors important for cell growth, proliferation, and survival (McCain 2013). BRAF is a "driver oncogene", frequently activated by point mutation in human cancer. For example, BRAF mutations have been identified in 50% of skin melanomas (Mackiewicz and Mackiewicz 2018), and also occur in colorectal cancer, papillary thyroid cancer, and non-small cell lung cancers (Halpenny et al. 2017). BRAF inhibitors vemurafenib and dabrafenib have been developed as treatments for BRAF-mutant melanoma (Fedorenko et al. 2015). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the residues near N-terminus of Human BRAF
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/200 | 1/500 |
| Western Blotting | |
1/100 | 1/200 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P15056
- Entrez Gene
- BRAF
- GO Terms
- GO:0005886 plasma membrane
- GO:0000186 activation of MAPKK activity
- GO:0005829 cytosol
- GO:0046872 metal ion binding
- GO:0005524 ATP binding
- GO:0005634 nucleus
- GO:0006916 anti-apoptosis
- GO:0007264 small GTPase mediated signal transduction
- GO:0007268 synaptic transmission
- View More GO Terms
- GO:0009887 organ morphogenesis
- GO:0048011 nerve growth factor receptor signaling pathway
MCA6328
155798
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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